ISRCTN23314770已完成未知
A randomised, double-blinded, placebo-controlled trial using cardiovascular magnetic resonance (CMR) scanning to assess remodelling and regression of fibrosis in cardiomyopathy with eplerenone
Record Provided by the NHSTCT Register - 2007 Update - Department of Health0 个研究点目标入组 140 人开始时间: 2007年9月28日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Stable patients with an established diagnosis of cardiomyopathy as assessed by history, examination and typical ECG/Echo findings who are on maximally tolerated doses of appropriate drugs with no changes being made to the prescription in the 2 months preceding the start of the trial.
排除标准
- •1. Patients already established on treatment with an aldosterone antagonist
- •2. Patients with contraindications to eplerenone (hyperkalaemia, renal failure)
- •3. Critically ill patients requiring respiratory and/or circulatory support
- •4. Pacemaker or ICD
- •5. Implanted ferromagnetic cerebrovascular clips
- •6. Pregnant women (precautionary only)
- •7. Intolerance of confined spaces
- •8. Inability to lie supine for 60 minutes
- •9. Unwilling or unable to give written informed consent
- •10.Atrial fibrillation or ventricular bigeminy
- •11. Any contraindication to CMR.
- •12. Recent MI
- •13. HCM patients who have received surgical/alcohol ablation treatment
研究者
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