RCT Comparing i-FACTOR and Allograft in Spinal Fusion Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 2
- 主要终点
- Oswestry disability index
研究概览
简要总结
The average life expectancy in Denmark is increasing resulting in an increasing part of the population having age-related disease, ex lumbar spinal stenosis (LSS). LSS causes constriction of the nerves in the lumbar spine resulting in pain in the legs and lower back, especially when standing and walking, known as neurogenic claudicatio(Goh KJ FAU - Khalifa et al.). LSS occurs in a combination of degenerative changes in the lower back, including hypertrophy of the ligamentum flavum, arthrosis of the facet joints and bulging of the disc.
Current treatment of LSS is varied ranging from non-operative conservative treatment to operation.
Operative intervention shows very good results according to physical ability and pain(Christensen FB et al.;Hee HT and Wong;McGregor AH FAU - Hughes and Hughes;Xu et al.), but the most optimal treatment is still debated. Nevertheless, a decompression and, if needed, a spinal fusion is recommended.
The investigators want to se whether i-FACTOR improves clinical outcomes compared to using allograft in spinal fusion in the elderly, and thereby find an improved methods operating this difficult patient population.
The hypothesis is, that there is no difference in clinical outcomes whether you use i-FACTOR or allograft i non-instrumented spinal fusion surgery in patients with spinal stenosis due to degenerative listhesis.
详细描述
Se above
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Spinal stenosis, listhesis grade 1-2 (>3 mm), facet joint arthrosis and flavum hypertrophia verified by a mr-scan and x-ray including maximally 2 levels ranging from L1-S
- •A score of 6 and more on Konno´s "History of Examination Characteristic".
- •Signed informed content.
排除标准
- •Any disease demanding obligate thromboprophylaxis treatment, including mechanical valve, (DVT with cancer/thrombophilia, AMI, apoplexia cerebri, TCI, valve-operation)< 3 months, coronar metal stent < 6 weeks and coronar drug eluted/coated stent < 12 months.
- •Atrial fibrillation and one of the following: Mitral stenosis, valve prothesis and apoplexia cerebri/TCI.
- •Atrial fibrillation and two of the following: Heart insufficient, HT, DM, age > 75 years, EF < 35 %.
- •Known cancer in the axial skeleton.
- •Ongoing chemotherapy.
- •Fracture i the lower back within a year prior to inclusion.
- •Reduced distance of walking due to non-spinal related causes.
- •Candidate for more than two-level intervention.
- •Dementia assessed by the MMSE
- •Age below 60 years.
- •Missed 3 months of conservative treatment without success
- •The use of steroids and bisphosphonates.
- •Prior radiotherapy to the lower back.
- •Haematologic disease. -
结局指标
主要结局
Oswestry disability index
时间窗: At 60 months
questionnaire
次要结局
- Walking distance(At 24 months)
- Fusion status yes/no(At 60 months)
- Dallas pain questionnaire(At 24 months)
- EQ5D(At 60 months)
- SF-36(At 60 months)
研究者
Karen Højmark Hansen
Research coordinator
Spine Centre of Southern Denmark