Investigation of the Effect of Fructose on Health Parameters and the Intestinal Barrier in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Changes in markers of intestinal permeability
研究概览
简要总结
The aim of the present study is to investigate the effect of fructose consumption on health parameters and the intestinal barrier in healthy individuals
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •all gender, healthy collective ≥ 18 years old
排除标准
- •Chronic inflammatory diseases of the gastrointestinal tract
- •Metabolic diseases or taking medication to treat metabolic diseases
- •Fructose malabsorption
- •Hereditary fructose intolerance
- •Food intolerances and/or allergies, as well as food allergies that require special dietary interventions
- •Special diets, such as vegetarian/vegan diets
- •Unstable body weight within the last 6 months (fluctuations of > 5%)
- •BMI < 19 kg/m2 & > 29,9 kg/m2
- •Bariatric surgery
- •Liver diseases
- •Renal insufficiency
- •Rheumatoid arthritis
- •COPD with ≥ 2 exacerbations per year
- •Chronic pancreatitis or recurrent acute pancreatitis
- •Alcohol consumption above 10 g/d for women and above 20 g/d for men
- •Pregnancy and breastfeeding
- •Viral or bacterial infections that occurred no longer than 3 weeks ago
研究组 & 干预措施
Glucose
Following a standardization of their nutritional intake for three days, participants will receive a drink supplemented with free glucose.
干预措施: Glucose (Other)
Fructose
Following a standardization of their nutritional intake for three days, participants will receive a drink supplemented with free fructose.
干预措施: Fructose (Other)
结局指标
主要结局
Changes in markers of intestinal permeability
时间窗: At the end of the treatment (1 month)
Changes in concentrations of bacterial endotoxin in blood plasma
Cytokine release from blood immune cells stimulated with bacterial toxins
时间窗: At the end of the treatment (1 month)
Changes in cytokine concentration in supernatant of immune cells before and after the treatments
次要结局
未报告次要终点
研究者
Prof. Dr. Ina Bergheim
Prof. Dr.
University of Vienna