Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Systemic (cutaneous) microcirculatory reactivity.
研究概览
简要总结
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
详细描述
An observational, cross-sectional study will be conducted, including volunteers aged ≥ 60 years, divided into two groups: elderly (60-80 years) and very elderly (>80). Young volunteers aged between 20 and 40 years, already participants in previous studies, whose demographic and microcirculation data are in the research laboratory's database, will be included as controls. Data from the control group will be obtained from an institutional database, respecting confidentiality and anonymization, in accordance with current ethical standards.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
- •Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.
排除标准
- •Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
- •Smoking: Active or quit less than 5 years ago.
- •Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
- •Surgery or trauma in the last 60 days.
- •Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
- •Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).
研究组 & 干预措施
very elderly (>80)
Evaluation of systemic microcirculation
干预措施: Assessment of Global Cognitive Function (Diagnostic Test)
elderly (60-80 years)
Evaluation of systemic microcirculation
干预措施: Laser Speckle Contrast Imaging (Diagnostic Test)
elderly (60-80 years)
Evaluation of systemic microcirculation
干预措施: Handgrip Dynamometry (Muscle Strength) (Diagnostic Test)
elderly (60-80 years)
Evaluation of systemic microcirculation
干预措施: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS) (Diagnostic Test)
elderly (60-80 years)
Evaluation of systemic microcirculation
干预措施: Single-Leg Balance Test (Diagnostic Test)
elderly (60-80 years)
Evaluation of systemic microcirculation
干预措施: Assessment of Global Cognitive Function (Diagnostic Test)
very elderly (>80)
Evaluation of systemic microcirculation
干预措施: Laser Speckle Contrast Imaging (Diagnostic Test)
very elderly (>80)
Evaluation of systemic microcirculation
干预措施: Handgrip Dynamometry (Muscle Strength) (Diagnostic Test)
very elderly (>80)
Evaluation of systemic microcirculation
干预措施: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS) (Diagnostic Test)
very elderly (>80)
Evaluation of systemic microcirculation
干预措施: Single-Leg Balance Test (Diagnostic Test)
结局指标
主要结局
Systemic (cutaneous) microcirculatory reactivity.
时间窗: up to 20 minutes
To analyze structural and functional changes in the microcirculation in different ages groups, with emphasis on microvascular endothelial senescence.
次要结局
- Muscle Strength(up to 10 minutes)
研究者
Eduardo Tibirica, MD, PhD
Senior Researcher
National Institute of Cardiology, Laranjeiras, Brazil