JPRN-UMIN000001152已完成4 期
Combination Therapy of Hypertension to Prevent Cardiovascular Events Trial - COPE Trial
COPE Trial Group0 个研究点目标入组 3,000 人开始时间: 2008年5月12日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 3,000
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 40years-old 至 85years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Seated systolic blood pressure >=200 mmHg or seated diastolic blood pressure >=120 mmHg 2. Secondary hypertension 3. Type 1 diabetes mellitus or type 2 diabetes on insulin treatment 4. History of cerebrovascular disorder, myocardial infarction, angina pectoris, coronary angioplasty or coronary artery bypass graft surgery within 6 months prior to enrolment in the study 5. Heart failure (NYHA functional classification II, III or IV) 6. Congenital heart disease or a history of rheumatic heart disease 7. Chronic atrial fibrillation or atrial flutter 8 Serious liver dysfunction (AST or ALT >=100 IU/l) or Serious renal dysfunction (serum creatinine >=2 mg/dl) 9. Severe peripheral arterial disease (Fontaine Class II, III or IV) 10. History of malignancy 5 years prior to study entry 11. Pregnancy 12. Compliance rate <70% assessed by a patient interview 13. Known hypersensitivity or contraindication to benidipine, angiotensin receptor blockers,beta-blockers, and thiazide diuretics 14. Other serious illness or significant abnormalities that the investigator judges inappropriate for the study
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