Comparative Effect of Theipoental and Propofol in IVF Outcome
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Fertilization rate
研究概览
简要总结
In this study the aim is to compare the effect of the type of anaesthetic drug used during oocyte retrieval on fertilization rates of oocytes retrieved after ovarian stimulation for in-vitro fertilization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women undergoing oocyte retrieval for IVF under general anesthesia
- •age ≤45 years
排除标准
- •women with a known hypersensitivity to the active substance of the investigating drugs or any of their excipients
研究组 & 干预措施
Propofol
In this arm patients will be receiving propofol for anaesthesia at doses 3-5mg depending on the time needed to complete oocyte retrieval
干预措施: Propofol (Drug)
Thiopental
In this arm patients will receive thiopental for anaesthesia at doses 7mg and a repeat dose of 2-3mg depending on the time needed to completed oocyte retrieval
干预措施: Thiopental (Drug)
结局指标
主要结局
Fertilization rate
时间窗: First 24h after oocyte retrieval
The number of oocytes fertilized divided by the number of oocytes in which fertilization was attempted per randomized patient
次要结局
- Number of MII oocytes(12h after oocyte rertieval)
- Implantation rate(40 days after embryo traansfer)
- The concentration of propofol or thiopental in the follicular fluid of the dominant (larger) follicle aspirated at oocyte retrieval(12 hours after oocyte retrieval)
- Pregnancy rate(14 days after embryo transfer)
研究者
E.M. Kolibianakis
Professor
Aristotle University Of Thessaloniki