Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
试验速览
- 阶段
- 不适用
- 入组人数
- 70,000
- 主要终点
- Postoperative respiratory complications
研究概览
简要总结
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9%
It has been shown that intra-operative protective ventilation is associated with a reduced risk of respiratory complications. The effects of intra-operative inspiratory oxygen fraction (FiO2) remain to be investigated.
In this study, the investigators aim to investigate the association between intra-operative FiO2 and respiratory complication as well as surgical site infection and ICU admission in patients undergoing non-cardiothoracic surgery. The investigators primary hypothesis is that high intra-operative FiO2 increases the risk of postoperative respiratory complications independent of predefined risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-cardiothoracic surgery at Massachusetts General Hospital between January 2007 and August 2015
- •Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure
- •above18 years of age
排除标准
- •Missing information regarding main characteristics or the exposure variable
研究组 & 干预措施
Patients undergoing surgery
All non-cardiothoracic surgical patients aged 18 years or above receiving general anesthesia at Massachusetts General Hospital between January 2007 and August 2014.
干预措施: Inspiratory oxygen (Drug)
结局指标
主要结局
Postoperative respiratory complications
时间窗: 7 days after surgery
次要结局
- Postoperative pulmonary edema(7 days after surgery)
- Postoperative surgical site infection(21 days after surgery)
- Postoperative mortality(30 days after surgery)
- Postoperative pneumonia(7 days after surgery)
- Postoperative admission to the intensive care unit(7 days after surgery)
- Postoperative respiratory failure(7 days after surgery)
- Postoperative length of stay(360 days after surgery)
- Postoperative reintubation(7 days after surgery)
研究者
Matthias Eikermann
MD, PhD, Associate Professor
Massachusetts General Hospital