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临床试验/NCT06491316
NCT06491316尚未招募不适用

Long Term Results of Cross-leg Free Vascularized Fibular Transfer for Reconstruction of Complex Post-traumatic Tibial Bone Defects: a Case Series Study

Assiut University1 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2024年7月20日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
22
试验地点
1
主要终点
Number of cases of Flap survival

研究概览

简要总结

This study aims to evaluate the new technique of cross-leg vascularized fibular graft for reconstruction of post-traumatic long tibial bone defects in terms of restoring normal anatomy and function of the traumatized limb in a series of cases admitted in Assiut University hospital, Orthopedics and trauma surgery department.

详细描述

Reconstruction of post-traumatic long tibial bone defects is still a major therapeutic challenge faced by orthopaedic surgeons on both anatomical and functional concerns, and it is usually associated with significant long-term morbidity. Historically, Amputation was the treatment of choice for long tibial bone defects because of difficulty of reconstructove management of such cases. Over the last few decades, Limb salvage procedures have been developed. During the second world war, massive cancellous bone autograft has been the preferred treatment. But traditional bone graft procedures in many cases may be limited by uncontrollable graft resorption. To overcome this disadvantage different management options have been developed to address bone defects of various lengths as vascularized fibular grafts, Ilizarov technique using bifocal or trifocal bone transport, acute limb shortening and masquelet procedure. However, In some cases long bone defects are associated with extensive soft tissue lacerations together with poor ipsilateral blood supply. For those cases previous surgical options are associated with many complications and may end up with failure of reconstruction and amputation, in this situation cross-leg vascularized fibular graft may be a good treatment option because it can provide a blood supply away from that of the extensively traumatized limb.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients who were admitted into Assiut University Hospital, Orthopedics and Trauma Surgery department with big tibial bone defects ranging from 12 cm to 26 cm, associated with extensive soft tissue damage and poor ipsilateral blood supply confirmed by CT angiography and treated with cross-leg free vascularized fibular graft.

排除标准

  • Patients with bilateral extensive soft tissue damage and poor blood supply.
  • Patients with medical conditions preventing them from general anesthesia for long periods (>10 hours).

结局指标

主要结局

Number of cases of Flap survival

时间窗: 6 weeks from operation

Flap intake and vascularization without necrosis

Number of cases of Bone healing

时间窗: 1 year from operation

Radiological evaluation

次要结局

  • Number of cases with accepted Limb alignment(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mahmoud Mohammad Saad

Demonstrator at Orthopedics and Trauma surgery department, Assiut university hospital

Assiut University

研究点 (1)

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