Myocardial Stress Perfusion Imaging With Dual Source CT
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
研究概览
简要总结
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan. The investigators hypothesize that a coronary CTA protocol can be devised to obtain resting myocardial perfusion, myocardial perfusion after stress, and coronary anatomy. Hence, one diagnostic test will be able to detect the presence of coronary plaque as well as assess the functional significance of a stenosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A prior adenosine or exercise stress SPECT exam with high likelihood of being referred to the cardiac catheterization laboratory for invasive angiogram
- •Age > 40 years old
- •Able to comprehend and sign the consent form.
排除标准
- •Acute coronary syndromes (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)
- •Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
- •Premenopausal women who have a positive pregnancy test.
- •Serum Creatinine level ≥1.5 mg/dl as an indicator of renal insufficiency.
- •Known allergy to iodinated contrast agents
- •Atrial fibrillation
- •Critical aortic stenosis
- •Systolic blood pressure < 90 mmHg
- •Advanced heart block
研究组 & 干预措施
Adenosine Stress Dual-source CTP
A multiphase adenosine Stress Dual-source stress perfusion computed tomography imaging test, as described above, will be performed in all patients.
干预措施: Adenosine Stress Dual-source CTP (Other)
结局指标
主要结局
Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
时间窗: 18 months
The gold standard for abnormality by CTP is defined as a focal stenosis of \>50% at quantitative analysis of invasive coronary angiography images, when performed.
Per-Vessel Specificity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
时间窗: 18 months
The gold standard for abnormality by CTP is defined as stenosis of 50% or more at quantitative analysis of invasive coronary angiography images, when performed.
次要结局
- Per-Patient Correlation Between CTP and SPECT at Stress.(18 months)
- Per-Patient Correlation Between CTP and SPECT at Rest.(18 months)
研究者
Brian Burns Ghoshhajra
Clinical Director, Cardiac CT and MRI, Department of Radiology
Massachusetts General Hospital