Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- apical closure assessed radiographically
研究概览
简要总结
the clinical trial aims to evaluate efficency of different scaffolds in cases of regeneration
详细描述
The aim of this study is to evaluate the clinical and radiographic outcome of regenerative endodontic procedures in immature non-vital permanent teeth using different nanoscaffolds (Platelet-rich fibrin, Mesoporous silica nanoparticles, Hyaluronic acid nanoparticles, Pomegranate nanoparticles)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 9 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients free from any systemic diseases that may interfer with the normal healing process.
- •Maxillary traumatized or cariously exposed non-vital immature anterior teeth.
- •Teeth don't need for post and core as a final restoration.
- •Radiographic evidence of an apical opening width more than 2 mm with or without periapical radiolucency.
- •Teeth without anatomical variations
排除标准
- •Immunocompromised patients
- •Teeth with previous endodontic treatment.
- •Teeth with internal or external resorption
- •Radiographic evidence of root fracture.
- •Lack of patient and parent cooperation.
- •Presence of periodontal pocket depth more than 4 mm.
研究组 & 干预措施
Pomegranate ( punica granatum) Extract Nanoparticles scaffold
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Pomegranate Extract Nanoparticles are synthesized from Punica granatum exract with potential antimicrobial and regenerative properties.
干预措施: Platelet rich fibrin (Procedure)
Hyaluronic Acid Nanoparticles scaffold (HA)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Hyalornic Acid nanoparticles are biodegradable with high water retention capacity promoting pulp tissue regeneration.
干预措施: Platelet rich fibrin (Procedure)
Mesoporous Silica Nanoparticles scaffold (MSN)
patients will recieve canal disinfection followed by induction of bleeding and injection of this scaffold directly before coronal sealing.
Mesoporous Silica Nanoparticles are biocompatible with high surface area that used as scaffold for enhancing the outcome.
干预措施: Platelet rich fibrin (Procedure)
Platelet Rich Fibrin (PRF only)
patients will recieve canal disinfection followed by induction of bleeding and placement of platelet rich fibrin as the only scaffold before coronal sealing.
platelet rich fibrin is obtained br removing the middle layer from a centrifuged blood sample and this is rich in platelets that play role in promoting tissue regeneration.
干预措施: Platelet rich fibrin (Procedure)
结局指标
主要结局
apical closure assessed radiographically
时间窗: 12 months after treatment
radiographic evaluation of apical closure as reduction or elimination of the apical opening of the root
次要结局
未报告次要终点
研究者
Nada Ahmed Hashad
Effect of Different NanoScaffolds on Pulp Regeneration in Non-Vital Immature Permanent Teeth (Randomized Clinical Trial)
Tanta University