NCT04896242已完成不适用
Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Global Longitudinal Strain (Left Ventricle)
研究概览
简要总结
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥18 year-old patients
- •With histologically confirmed thoracic cancer (breast, esophagus or lung)
- •Recommendation of thoracic radiotherapy (RT) with curative intent
- •With or without chemotherapy
- •All patients must be able to read and understand Spanish
- •All patients must sign informed consent form.
排除标准
- •Patients with no medical records,
- •Previously diagnosed with severe left ventricular dysfunction or a cardiac insufficiency
- •Patients with metastatic disease and indication of palliative RT
- •Patients with significant comorbidities associated to a <5 year life expectancy.
- •Patients previously treated with thoracic RT
结局指标
主要结局
Global Longitudinal Strain (Left Ventricle)
时间窗: Baseline, 1 and 12 weeks after Treatment
\>5 Absolute drop or 12% Relative reduction from baseline
次要结局
- Cardiac Magnetic Resonance Anatomical Image(Baseline, 1 and 12 weeks after treatment)
- Cardiac Magnetic Resonance Quantitative Image(Baseline, 1 and 12 weeks after treatment)
- Cardiac Magnetic Resonance Cinema Imaging(Baseline, 1 and 12 weeks after treatment)
- Cardiac Magnetic Resonance Flow Image(Baseline, 1 and 12 weeks after treatment)
研究者
研究点 (1)
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