NCT07655518招募中1 期
A Phase 1, Open-label, Positron Emission Tomography (PET) Imaging Study to Evaluate M4 Muscarinic Acetylcholine Receptor Occupancy in the Central Nervous System Using [11C]MK-6884 PET Tracer Before and After Oral Administration of Multiple Doses of BMS-986521 in Healthy Adult Participants
Bristol-Myers Squibb1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2026年6月25日最近更新:
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 12
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must be healthy male and female (as assigned at birth) who are individuals not of childbearing potential (INOCBP) without clinically significant deviation from normal in medical history, PE, 12-lead ECG, and clinical laboratory assessments.
- •Participants must have a BMI of 18 to 30 kg/m^2, inclusive, and total body weight ≥ 50 kg.
排除标准
- •Participants must not have presence or history of any clinically relevant abnormality, condition, or disease-CNS, cardiovascular, renal, hepatic, hematologic, GI, endocrine, pulmonary, psychiatric, neurologic (eg, seizure disorder), or immunologic.
- •Participants must not have history of rhabdomyolysis.
- •Participants must not have current or recent (within 3 months of study intervention administration) clinically significant GI disease.
- •Other protocol defined inclusion/exclusion criteria apply.
研究组 & 干预措施
BMS-986521: Cohort 1
Experimental
干预措施: BMS-986521 (Drug)
BMS-986521: Cohort 2
Experimental
干预措施: BMS-986521 (Drug)
BMS-986521: Cohort 3
Experimental
干预措施: BMS-986521 (Drug)
研究者
研究点 (1)
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