NCT01429948已完成不适用
Novel Biomarkers for Personalized Therapy in Korean Patients With Ischemic Stroke
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 581
- 试验地点
- 1
- 主要终点
- Frequency and amount of right-to-left shunts (RLS) on agitated saline TCD monitoring
研究概览
简要总结
We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory. In the present study, we evaluated the association between SCI and paradoxical embolism detected by agitated saline transcranial Doppler (TCD) monitoring in healthy subjects without history of stroke or transient ischemic attack (TIA). We also compared the frequency and amount of paradoxical embolism between healthy subjects with SCI and acute stroke patients with presumed cryptogenic embolism or conventional stroke mechanisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy subjects
- •Subjects with age over 20 years
- •Subjects who consecutively visited a health promotion center for a health screening examination that included routine laboratory test, cardiac work-ups (12-lead electrocardiography and/or echocardiography), and brain magnetic resonance image (MRI) and MR angiography (MRA)
- •Subjects who showed silent brain infarction (SCI) which was defined as a focal hyperintensity lesion 3 mm or large in diameter in the fluid-attenuation inversion recovery (FLAIR) images without a history of a corresponding stroke or transient ischemic attack (TIA)
- •Subjects who performed agitated saline transcranial Doppler (TCD) monitoring
- •Patients with acute stroke (both cryptogenic embolic stroke and conventional stroke mechanisms)
- •Patients with age over 20 year
- •Patients with focal neurologic deficits presented within 7 days of symptom onset
- •Patients with acute ischemic lesions on diffusion-weighted image (DWI)
- •Patients who performed agitated saline TCD monitoring
排除标准
- •Healthy subjects
- •Subjects with the presence of previous history of stroke or TIA
- •Subjects with the presence of dementia on history taking or mini-mental status examination
- •Subjects with the presence of proximal source of embolism, including atrial fibrillation or significant (≥50%) stenosis on cervicocerebral artery on MRA or carotid Duplex
- •Subjects who had SCI restricted within perforator territory (basal ganglia or pons) suggesting that microangiopathy rather than embolism could be the main mechanism of SCI
- •Subjects in whom agitated saline TCD monitoring was not performed or those who had poor temporal windows
- •Patients with acute stroke (both cryptogenic embolic stroke and conventional stroke mechanisms)
- •Patients in whom agitated saline TCD monitoring was not performed or those who had poor temporal windows
结局指标
主要结局
Frequency and amount of right-to-left shunts (RLS) on agitated saline TCD monitoring
时间窗: Within a month after MRI scanning
次要结局
未报告次要终点
研究者
研究点 (1)
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