Clinical Diagnosis of Acute Porphyria
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 6
- 主要终点
- Other possible causes of mildly elevated porphyrins and recurrent pain
研究概览
简要总结
The purpose of this study is to test whether a focused questionnaire and laboratory tests can better define risk factors associated with possible genetic porphyria. The investigators hypothesize that the genetic carrier state of acute porphyria is distinctive enough that the Genetic Carrier Profile the investigators devise through this study will be useful in identifying carriers of genetic porphyria among the large population with undiagnosed abdominal pain.
详细描述
The porphyrias are a group of genetic diseases caused by disturbances in the formation of heme, an essential component of hemoglobin and other proteins, leading to either acute (neurologic) and/or chronic (cutaneous) symptoms. Acute porphyria is often difficult to diagnose because symptoms may not be specific and, unless the patient is in an active attack, laboratory values typically may not be useful for diagnosing porphyria. The purpose of this study is to test whether a focused questionnaire and laboratory evaluation tool can better define risk factors associated with possible genetic porphyria. The goals of this study are:
- To determine the presence and number of abnormal lab tests and porphyria-like symptoms in adult family members of the first person in a family who has been diagnosed with a disease of acute porphyria, 50% of whom are expected to carry the same genetic defect of the index case.
- To devise a Genetic Carrie Profile that could be used to screen people in whom the diagnosis of porphyria is being considered.
- To test the Profile in patients with symptoms suggestive of HCP and/or urine tests showing some elevation of porphyrins.
- To explain other possible causes of minor increases in porphyrin levels in patients with recurrent abdominal pain who have not been diagnosed with porphyria
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be 15 years of age or older
- •Be a first-degree relative (child, sibling, parent, or grandparent) of an individual with genetically proven acute porphyria (AIP, HCP or VP)
- •Not have had any previous genetic testing for acute porphyria
- •Group 2 Inclusion Criteria:
- •Be 15 years of age or older
- •Have a history of suggestive clinical features, such as abdominal, back or limb pain, recurrent nausea lasting days, reaction to medications, psychiatric history, or sun sensitivity.
- •An increase in urinary, fecal or serum porphobilinogen (PBG) and/or porphyrins
- •Groups 1 and 2
排除标准
- •Have previously had genetic testing for acute porphyria
- •Have a history of "alarm" symptoms, such as anemia, unintentional weight loss, signs of GI (gastrointestinal) bleeding, or dysphagia (difficulty in swallowing).
- •Follow Up Sub-Study (Group 3) Inclusion Criteria:
- •Have been seen by one of the Porphyria Consortium physicians/investigators 10 or more years prior to study initiation
- •Had a slight increase in porphyrins during the initial visit
- •Not given a diagnosis of porphyria at the time of the visit
- •Follow Up Sub-Study (Group 3) Exclusion Criteria:
- •You have been seen by the Porphyria Consortium physician/investigator less than 10 years prior to study initiation.
结局指标
主要结局
Other possible causes of mildly elevated porphyrins and recurrent pain
时间窗: Assessed once during a one-time telephone or in-person interview
Participants in the Follow-up Sub-study section of this protocol will be interviewed concerning other possible causes of mildly elevated porphyins and recurrent pain. These will be patients previously seen by the investigator who were deemed not to have porphyria.
Clinical features suggestive of the acute porphyria carrier state
时间窗: Assessed once at baseline visit for all subjects
Through a focused questionnaire, we will determine the typical duration of pain attacks.
Acute porphyria genetic carrier state
时间窗: Assessed once at baseline visit for all subjects
All subjects will undergo DNA analysis to detect a mutation in the HMBS, CPOX, or PPOX genes, respectively.
Presence of heavy metals
时间窗: Assessed once at baseline visit for all subjects
All subjects will undergo a blood test to screen for the presence of heavy metals as a cause for minor elevations of porphyrin levels.
Validity of Genetic Carrier Profile
时间窗: The profile will be tested once during the baseline visit for subjects in Group 2.
The biochemical and clinical features of genetically proven but asymptomatic HCP will be tabulated and compared to subjects who are not genetic carriers. Its accuracy in predicting risk factors for HCP will be tested in subjects in Group 2.
Presence of positive biochemical features by second-line testing in subjects suspected of being a genetic carrier of acute porphyria
时间窗: Assessed once at baseline visit for all subjects
All subjects will be assessed for any elevations and levels of fractionated quantitative fecal porphyrins.
Presence of positive biochemical features by first-line testing in subjects suspected of being a genetic carrier of acute porphyria
时间窗: Assessed once at baseline visit for all subjects
All subjects will be assessed for any elevation of quantitative urine porphobilinogen (PBG).
次要结局
- Prevalence of HCP in a population with elevation of urine coproporphyrin and pain symptoms.(Assessed once enrollment and genetic testing of subjects in Group 2 are complete - after a 1-year recruitment and enrollment period.)
- Frequency of disease manifestations in genetically confirmed AIP and HCP(Assessed annually for 5 years)