Association Between Uterine , Intracavitary , Cervical and Cervical Canal Lesions With in Vitro Fertilization/Intracytoplasmic Sperm Injection(IVF/ICSI) Outcome.
试验速览
- 阶段
- 不适用
- 入组人数
- 122
- 主要终点
- Pregnancy rate
研究概览
简要总结
- To study the effect of uterine wall , intracavitary , cervical as well as cervical canal lesion on the outcome of IVF/ICSI cycle.
- To establish a score for prediction of IVF/ICSI cycle success .
详细描述
IVF is one of the most successful treatment of fertility, (1) however, several IVF cycles fail to achieve pregnancy (2).failure defined as three or more failed attempts of ICSI (3). Implantation failure is a complex in nature, may be due to structural or functional causes (3, 4).
that previously undiagnosed, misinterpreted initial diagnoses, or subtle newly added intrauterine abnormalities may be a significant cause of IVF failure (5, 6), studies say that intra-uterine pathologies represent 40-50 % of causes of ICSI failure (7, 8), hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum, or intrauterine adhesions could increase the pregnancy rate (9). so, Evaluation of the uterine cavity may become a routine investigation before assisted reproductive technology(ART) procedures (10).
In this study, we evaluate the relationship between the different uterine and cervical pathologies and decreased live birth rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women between 18 and 38 years old.
- •An indication for IVF/ICSI..
- •Women with BMI between 18.5 : 29.9 .
- •Women with normal antimullerian hormone(AMH), antral follicle count(AFC) (good responders).
排除标准
- •Refusal to join the study.
- •Women with age less than 18 and more than 38 .
- •Women with BMI less than 18.5 and more than 30 .
- •Untreated tubal hydrosalpinges.
- •Poor responders as assessed by AFC 4 or less ,AMH O.8 ng/dl (nice 2013).
结局指标
主要结局
Pregnancy rate
时间窗: Baseline
Pregnancy rate with IVF/ICSI with uterine lesions
次要结局
未报告次要终点
研究者
Khaled Mostafa Ahmed
doctor
Assiut University