NL-OMON35861已完成不适用
GABAergic modulation of alpha and gamma oscillations: implications for working memory maintenance - GABAergic modulation of alpha and gamma oscillations
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Healthy volunteers between 18 and 35 years of age.
- •Predominant right-handedness
排除标准
- •Abnormal hearing or (uncorrected) vision.
- •Average use of more than 3 alcoholic beverages daily.
- •History of prescribed medication within the month prior to the start of the study
- •History of *over the counter* medication or cannabis usage within 2 months prior to the start of the study with exception of occasional use of paracetamol.
- •History of drug (opiate, LSD, (meth)amphetamine, cocaine, solvents, cannabis, or barbiturate) or alcohol dependence.
- •Average use of psychotropic medication or recreational drugs weekly or more.
- •Habitual smoking, i.e. more than a pack of cigarettes per week and a self-reported inability or unease to cease smoking for 24 hours prior to testing.
- •Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement.
- •Regular use of corticosteroids.
- •Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices).
- •(History of) psychiatric treatment.
- •(History of) neurological treatment.
- •(History of) endocrine treatment.
- •(History of) autonomic failure (e.g., vasovagal reflex syncope).
- •(History of) clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic or pulmonary disease.
- •(History of) epilepsy.
- •(History of) Raynaud*s syndrome.
- •Uncontrolled hypertension, defined as diastolic blood pressure at rest > 90 mmHg or systolic blood pressure at rest > 160 mmHg.
- •Hypotension, defined as diastolic blood pressure < 60 mm Hg or systolic < 100 mm Hg or resting pulse rate < 50 beats/min.
- •Glaucoma.
- •Heart disease.
- •Kidney disease.
- •Liver disease.
- •Lung/breathing problems.
- •Sleep apnea.
- •Muscle weakness.
- •Current parodontitis.
- •Diabetes.
- •Family history of schizophrenia, bipolar disorder or major depressive disorder.
- •Body Mass Index < 19 or > 30.
- •Claustrophobia.
- •Intense daily physical exercise.
- •Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
- •Possible pregnancy or breastfeeding.
- •Increased risk for glaucoma.
研究者
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