ISRCTN98806770已完成不适用
On the dynamics of the hypothalamus-pituitary-adrenal axis response to prolonged critical illness: a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 562
研究概览
简要总结
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30215187
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •For patients:
- •1. Critically ill patients admitted for =7 days to one of the five ICUs from two departments (medical and surgical) in the University Hospitals Leuven
- •2. Age =18 years
- •For healthy volunteers:
- •1. Age-, gender- and BMI-matched to the included patients
排除标准
- •For patients:
- •1. Predisposing factors of adrenal insufficiency:
- •1.1. Cerebral disease with intracranial hypertension threatening the neuroendocrine system
- •1.2. Pituitary disorders including (pan)hypopituitarism
- •1.3. Known adrenal disease (Cushing's syndrome or Addison's disease)
- •1.4. Treatment with glucocorticoids, other steroids or anti-steroid chemotherapy within the last 3 months
- •1.5. Use of etomidate within the last 72 hours
- •1.6. Other drugs predisposing to adrenal insufficiency: azoles, phenytoin, rifampicin, glitazones, imipramin, phenothiazine, phenobarbital
- •2. No arterial line in place
- •3. Ethical restrictions:
- •3.1. Moribund
- •3.2. Declined participation
- •For healthy volunteers:
- •1. Recent history of treatment with HPA-axis interfering drugs
研究者
相似试验
已完成
不适用
Detection of enhanced hormonal production in male athletesOvertraining syndromeISRCTN12177010Federal University of São Paulo40
已完成
不适用
Evaluation of endocrine complications in patients with long-term epidural steroid injectionsDiseases of the musculo-skeletal system and connective tissueKCT0004828The Catholic University of Korea, Yeouido St. Mary's Hospital30
已完成
不适用
Peacock - a paediatric cortisol studyPaediatric patient undergoing cardiac surgery and other cardiac investigationsCirculatory SystemISRCTN98258655niversity Hospitals Bristol NHS Foundation Trust52
进行中（未招募）
不适用
Hypothalamus-Pituitary-Adrenal Axis function in the topical management with clobetasol propionate of oral lichen planus (OLP - NDMedDRA version: 9.1Level: LLTClassification code 10030983Term: Oral lichen planusoral lichen planusEUCTR2009-010357-12-ITPOLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
招募中
1 期
Examination regarding hypothalamus-pituitary-adrenal axis activity in mood disorder and post-traumatic stress disorder (PTSD) as determined by Dexamethasone/corticotropin releasing hormone (DEX/CRH) testmood disorder, post-traumatic stress disorderJPRN-UMIN000004082Gunma University Graduate School of Medicine300