Methadone dose adjustments, plasma R-methadone levels and therapeutic outcome of opioid addiction - Methadone doses and heroin dependence

niversita' di Firenze; Dipartimento di Farmacologia Preclinica e Clinica0 个研究点开始时间: 2008年10月17日最近更新: 2014年3月10日

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•Eligible patients are heroin addicts aged 21-55 years requiring admission to a methadone maintenance treatment in the existing services for drug addicts (SERT) or in the Toxicology Unit, Florence University and Careggi Hospital. Pregnant women will also be included. The following are the other inclusion criteria: 1) opioid dependence lasting at least 3 years 2) more than 3 documented previous attempts to reach an opioid-free state 3) negative HIV test; 4) non obvious perception disorders 5) fluency in Italian and ability of reasonably fill up the opioid addiction treatment forms (see: annex); 6) residency in the larger Florence area (this in order avoiding enrolment of patients that will be forced to abandon the therapeutic program because of family reason or enforcement of immigration law. The following are the exclusion criteria 1) age outside the range 21-55 years 2) recent heroin dependence (dating less than 3 years with no previous attempts of achieving a drug-free state). 3) Schizophrenia 4) Positive HIV test 5) Liver Cirrhosis 6) Cancer 7) Heart failure 8) Inability to understand the aim and the conduct of the study.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•The following are the exclusion criteria 1) age outside the range 21-55 years 2) recent heroin dependence (dating less than 3 years with no previous attempts of achieving a drug-free state). 3) Schizophrenia 4) Positive HIV test 5) Liver Cirrhosis 6) Cancer 7) Heart failure 8) Inability to understand the aim and the conduct of the study.

发起方

niversita' di Firenze; Dipartimento di Farmacologia Preclinica e Clinica