Defining the Serum Ferritin Concentration in Kenyan Women and Their Preschool Children at Which the Body Senses Iron Depletion and Begins to Upregulate Iron Absorption From the Diet
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 275
- 试验地点
- 1
- 主要终点
- Fractional iron absorption
研究概览
简要总结
Using standardized methods, the investigators will perform stable iron isotope absorption studies in young Kenyan women and their preschool children (2-5y of age) with varying iron status to measure iron absorption from maize meal containing labeled ferrous sulfate. Using these data, this study aim is to define the ferritin in these young women and children at which the body senses iron depletion and begins to upregulate iron absorption from the diet; this approach could provide a functionally defined threshold of iron deficiency in Sub-Saharan African women and children.
详细描述
In this experimental study in southern Kenya, the investigators will take a baseline venous blood sample to measure iron and inflammation biomarkers in generally healthy young women (n=125) and in their preschool children. The investigators will then administer, after an overnight fast, a standardized test meal porridge made from refined maize and bottled water containing the stable iron isotope 57Fe. Fourteen days later, the investigators will take a second venous blood sample for determination of erythrocyte incorporation of the 57Fe to measure iron absorption from the labeled test meal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI between 17 - 27.5 kg/m2
- •No acute illness (self-reported)
- •No metabolic or gastrointestinal disorders (self-reported)
- •No use of medication affecting iron absorption or metabolism during the study
- •No intake of mineral/vitamin supplements 2 weeks prior to the first study visit and during study
- •Mother of a preschool age child (2-5 years)
- •Child has normal Z-scores for WAZ, HAZ and WHZ (-3 - +3)
排除标准
- 未提供
结局指标
主要结局
Fractional iron absorption
时间窗: Study day 14
Erythrocyte iron incorporation
次要结局
- Serum ferritin(Study day 1)
- soluble transferrin receptor(Study day 1)
- C-reactive protein(Study day 1)
- alpha(1)-acid-glycoprotein(Study day 1)
研究者
Isabelle Herter-Aeberli
PhD
Swiss Federal Institute of Technology