Functional MRI in Older People Following Hip Fracture Surgery: a Feasibility Study
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 主要终点
- Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process
研究概览
简要总结
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
详细描述
Postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. Hip fracture surgery is a procedure associated with an increased risk of postoperative delirium.
In the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed.
People who have recovered from post operative delirium and people who did not have postoperative delirium will be included.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 65 years
- •Cognitively intact
- •primary admission for hip fracture surgery
排除标准
- •Cognitive impairment
- •Less than moderate level of activities of daily living
- •History of neurosurgery/significant head trauma
- •Acutely unwell/moribund
- •Presence of neurological diseases including overt stroke, dementia, multiple sclerosis, Parkinson's disease, intracranial tumours and other significant neurologic disorders.
- •Postural or movement disorders likely to impede MRI scan
- •Contraindications to MRI
- •Complex fractures/multiple injuries
结局指标
主要结局
Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process
时间窗: From time of consent to day after MRI scan which is up to 5 days
The feasibility of transferring participants to and achieving structural and functional MRI scans. Specifically we will assess the number of participants in whom scans were successfully achieved
次要结局
- Pain assessment.(From immediately prior to transfer to the MRI suite until return to own hospital bed which is approximately 2 hours)
- Participant feedback(Two occassions. The first immediately after return from the MRI scan suite. The second will occur the day after scanning. Each will take 5 minutes.)
- Abnormalities of functional connectivity(Up to one month after scans have been achieved)
- Actual times taken to achieve scans(Up to 60 minutes)