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临床试验/NCT03102086
NCT03102086Unknown不适用

The Association Between Nephrolithiasis and Periodontal Status

Rambam Health Care Campus1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2017年5月11日最近更新:
适应症

试验速览

阶段
不适用
入组人数
20
试验地点
1
主要终点
the composition of both specimens

研究概览

简要总结

Dental calculus is a calcified deposits firmly attached to teeth and implants surfaces. Dental calculus is strongly associated with periodontitis and considered to have indirect role in the pathogenesis of periodontal diseases. Dental calculus composed primarily of calcium phosphate mineral salts originated in the saliva covered by unmineralized bacterial layer. Composition of calculus varies from person to person and influenced by numerous variables such as: age, gender systemic disease and ethnic background.

Nephrolithiasis (kidney stones) are composed of insoluble salts of constituents of the forming urine. The most two frequent stone types are: Calcium oxalate (with a frequency of 15% -35%) and Calcium phosphate (5% -20%). The prevalence of kidney stones varies with race, sex, and geographic location. In the United States for men, kidney stone rates vary between 4%-9%, and for women, kidney stone rates range between 2%-4%.

Previous studies dealt with the connection between sialolithiasis and nephrolithiasis were inconclusive. To the authors' best knowledge no studies were done to examine the associations between nephrolithiasis and dental calculus. Thus, the aim of this study is to compare the mineral composition of both dental calculus and nephrolithiasis and determine whether nephrolithiasis composition may be linked to the periodontal status.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients diagnosed with nephrolithiasis
  • Over 18 years old

排除标准

  • Pregnant woman, uncontrolled diabetes (HbA1c > 7.5%), patients who received periodontal treatment in the past 6 months, smokers

结局指标

主要结局

the composition of both specimens

时间窗: the analysis will take 9 months

The X-ray diffraction of both kidney stone and dental calculus will result in the composition of the two, and comparison will be done

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

machtei

Prof

Rambam Health Care Campus

研究点 (1)

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