Impacts of staged bilateral pallidotomy or campotomy on non-motor symptoms in Parkinson's disease.

Hospital Santa Marcelina0 个研究点开始时间: 2018年4月18日最近更新: 2023年5月29日

适应症

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•Patients with Idiopathic Parkinson's Disease; clinical Indication for neurosurgical treatment for Parkinson's disease;
•Age greater than 18 Years;
•Stage two or greater on Hoehn and Yahr Scale in the absence of medication.
•Presence of significant motor dysfunction during three or more hours per day despite receiving adequate drug treatment;
•Persistence of motor dysfunction under revised and adequated medication regimen for at least 1 month;
•Consent to participate in the defined evaluations; Consent to perform surgical procedure with the purpose of treating Parkinson's symptoms;
•Patients who sign the Informed Consent Form according to the Norms of the Research Ethics Committee of Santa Marcelina Hospital.

•Patients with parkinsonism associated with another degenerative disease such as Multi-systemic Atrophy; Dementia by Lewy Bodies; Alzheimer's disease; Cortico-Basal degeneration; Fronto-temporal dementia; cerebellar ataxia. Patients with suspected secondary parkinsonism such as cerebral vascular disease; Use of medications; Normal pressure hydrocephalus; Traumatic brain injury. Patients with previous surgical treatment for Parkinson's Disease as pallidotomy; talamotomy or electrode Implant for deep brain stimulation. Patients with clinical or cardiologic contraindications to perform the surgical procedure. Current use of neuroleptic drugs for the treatment of behavior disorders or hallucinations associated with the use of dopaminergic drugs. Patients with schooling Level very Low (below 2 Years) or with auditory or visual deficiency, in such a way as to Inviabilize neuropsychological evaluation. Personal history of alcohol abuse.
•Diagnosis of current severe depression, according to DSM-IV criteria - American Psychiatric Association 2000. Patients with dementia diagnosis associated with Parkinson's disease according to the criteria stablished by the movement disorders society.

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