National Collaborative Study of Girls Prenatally Diagnosed With Turner Syndrome Karyotypes
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number of signs of Turner syndrome
研究概览
简要总结
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
详细描述
This is an observational study which will look at girls who are diagnosed with Turner syndrome before they are born. Girls will be divided into two groups: 1) those diagnosed because of features seen on ultrasound which raised the question of Turner syndrome and 2) those diagnosed incidentally when their mother had an amniocentesis for another reason such as advanced maternal age.
No clinical procedures nor interventions will be done as part of this data collection study which will occur for the first 3 to 6 years of the girl's life. The investigators will be looking to see if girls who are diagnosed incidentally have less features of Turner syndrome than those girls who are diagnosed because of fetal ultrasound.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 3 Months（Child）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Turner syndrome diagnosed prenatally
- •Less than 4 months of age at time of enrollment
排除标准
- •Turner syndrome diagnosed postnatally
- •Older than 4 months of age at time of enrollment
结局指标
主要结局
Number of signs of Turner syndrome
时间窗: three to six years
Girls diagnosed with Turner syndrome by fetal ascertainment will have more signs of Turner syndrome than girls diagnosed by maternal ascertainment
次要结局
- Growth(three to six years)
研究者
Patricia Fechner
Associate Professor, Pediatrics
Seattle Children's Hospital