ISRCTN10537092已完成未知
Determining the role of Wnt signalling & IGFBP6 in enhanced atherosclerosis risk in periodontal patients: biomarker & therapeutic potential evaluation
niversity of Bristol0 个研究点目标入组 274 人开始时间: 2022年7月15日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 274
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •People with periodontitis:
- •1. All people over the age of 18 years
- •2. Capacity to consent
- •3. Attending a scheduled dental appointment at the University of Bristol Dental Hospital
- •4. People with unstable severe periodontitis or a high susceptibility to periodontitis ( as defined by the British Society of Periodontology 2019 implementation of the 2017 World Workshop Classification of periodontal and peri-implant diseases and conditions: Stage III/IV and Grade C. )
- •5. At least 18 erupted teeth
- •Healthy volunteers:
- •6. All people over the age of 18 years
- •7. Capacity to consent
- •8. Attending a scheduled dental appointment
- •9. People with no evidence of periodontitis
- •10. At least 18 erupted teeth
排除标准
- •Exclusion criteria for people with periodontitis:
- •1. All people under the age of 18 years
- •2. Those who lack capacity to consent
- •3. History of cardiovascular disease such as hypertension, angina, previous myocardial infarction, heart failure, aortic disease, arrhythmia, heart valve disease.
- •4. History of autoimmune/autoinflammatory diseases such as Sjogren's syndrome, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, or systemic sclerosis
- •5. History of endocrine disease including diabetes mellitus types 1 and 2
- •6. Currently taking antibiotics or has had antibiotics in the preceding 6 months
- •7. People taking statins, non-steroidal anti-inflammatory medications, immunosuppressive medications or corticosteroids.
- •8. Smokers of tobacco (including Vaping/e-cigarettes)
- •9. History of salivary gland disease or oral mucosa disease
- •Exclusion criteria for healthy volunteers:
- •10. All people under the age of 18 years
- •11. Those who lack capacity to consent
- •12. History of cardiovascular disease such as hypertension, angina, previous myocardial infarction, heart failure, aortic disease, arrhythmia, heart valve disease
- •13. History of autoimmune/autoinflammatory diseases such as Sjogren's syndrome, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, or systemic sclerosis
- •14. History of endocrine disease including diabetes mellitus types 1 and 2
- •15. Currently taking antibiotics or has had antibiotics in the preceding 6 months
- •16. People taking statins, non-steroidal anti-inflammatory medications, immunosuppressive medications or corticosteroids.
- •17. Smokers of tobacco (including Vaping/e-cigarettes)
- •18. History of salivary gland disease or oral mucosa disease
研究者
相似试验
尚未招募
不适用
nderstanding the scar tissue after burn injuryCTRI/2020/09/028120Symbiosis International University
招募中
1 期
Clinical significance and molecular mechanism of Wendan Decoction in early intervention of phlegm-dampness metabolic syndromeITMCTR2200005829Shunde District Hospital of Chinese Medicine of Foshan City
招募中
3 期
Relationship between IL6 and fatigue induced by radiotherapy and chemotherapy in patients treated with Melatonin drugBreast CanceCancer Related FatigueMelatoninInterleukin 6.Malignant neoplasm of breastIRCT20180426039421N2Hamedan University of Medical Sciences64
撤回
不适用
Effect of the BDNF Val66Met related morphological differences in the brain on transcallosal connectivityNL-OMON32916Radboud Universiteit Nijmegen80
尚未招募
不适用
CYTOKINES(INFLAMMATORY MARKERS) IN SEVERE AND MODERATE COVID 19 PATIENTS AND ITS RELATION WITH THE OUTCOMESCTRI/2020/12/030082PAVULURI KRISHNA SWATHI