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临床试验/NCT03450538
NCT03450538已完成不适用

Is Computed Tomography Associated With Survival in Adult Trauma Patients in an Urban Lower-middle Income Setting?

Karolinska Institutet4 个研究点 分布在 1 个国家目标入组 16,000 人开始时间: 2018年1月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
16,000
试验地点
4
主要终点
30 day in hospital mortality

研究概览

简要总结

This study is aimed at assessing the survival benefit potentially associated with CT scans for trauma patients in an urban lower-middle income setting.

详细描述

Background

Trauma is defined as an injury caused by an external force to the body. Trauma is one of the major causes of death in the world and accounts for almost five million deaths per year. To quickly and accurately assess damage to internal organs and to be able to identify the potentially fatal injuries, various forms of imaging are used. Examples of such imaging are conventional x-ray scans, Focused Assessment by Sonography in Trauma (FAST), and Computed Tomography (CT). In high-income countries, it has become common to utilize CT as a routine investigation in trauma patients.

The use of whole body CT (WBCT) scans as opposed to selective scanning has been associated with survival benefits for trauma patients, even when the patients undergoing WBCT have more severe injuries than the control group. The studies that investigate this association have been done mostly in high-resource settings where the distance between resuscitation and imaging facilities are short, imaging facilities are more readily available, and the quality of the imaging may be better.

Trauma disproportionally affects low-resource settings. For example, road traffic injuries are responsible for more than 1,3 million deaths per year and of these approximately 90 percent occur in low- and middle-income countries. In low-resource settings the CT may be located far from the resuscitation and surgical resources, and the expertise needed to keep patients stable during the transfer to and from the CT may be limited. Therefore, it is unclear if the survival benefit associated with CT use in high-resource settings also can be observed in low-resource settings.

Aim

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
15 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Presented alive
  • Direct admission
  • ≥ 15 years old

排除标准

  • 未提供

结局指标

主要结局

30 day in hospital mortality

时间窗: 30 days

Death in hospital within 30 days of arrival to participating centre. Patients who were discharged alive before 30 days were assumed to be alive at 30 days.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Martin Gerdin

Researcher

Karolinska Institutet

研究点 (4)

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