Dead Space Evaluation During Exercise in Patients With Pulmonary Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 主要终点
- dead space ventilation (measured in L/min)
研究概览
简要总结
Aim of the study is to evaluate the role of chemoreceptor activity and ventilation perfusion mismatch on the genesis of exercise induced hyperventilation in Pulmonary hypertension patients. So the investigators tested the chemoreceptor response at rest, both with hypoxic and hypercapnic stimuli, and the ventilatory response during exercise analyzing its two components, alveolar and dead space ventilation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 and ≤ 80 years
- •ability to understand the research protocol and willing to sign the study informed consent
- •diagnosis of pulmonary arterial hypertension belonging to Class I and IV
- •stable haemodynamic status and optimized medical treatment since at least 2 months
- •ability to perform maximal cardiopulmonary exercise test and pulmonary diffusing capacity for carbon monoxide evaluation
排除标准
- •relevant comorbidities
- •usual contraindications for cardiopulmonary exercise test
- •pulmonary hypertension associated to left heart and pulmonary disease, congenital heart diseases with evident cardiac shunts.
研究组 & 干预措施
Pulmonary hypertension patients
All Pulmonary hypertension patients enrolled in the study underwent a cardiopulmonary exercise test and hypoxia and hypercapnia tests
干预措施: cardiopulmonary exercise test,hypoxia and hypercapnia test (Other)
结局指标
主要结局
dead space ventilation (measured in L/min)
时间窗: 1 week
Dead space ventilation is calculated through the equation: VT\* \[1- (863\*VCO2)/(VE\*PaCO2)\], where VT = tidal volume, VCO2= CO2 output, VE= pulmonary ventilation,PaCO2 is the arterial partial pressure of CO2 and 863 is a constant.
次要结局
- central hypercapnic chemosensitivity (measured in L/min/mmHg)(1 week)
- peripheral response to hypoxia (measured in L/min/O2)(1 week)
- peripheral response to hypercapnia (measured in L/min/mmHg)(1 week)
研究者
Piergiuseppe Agostoni
Professor
Centro Cardiologico Monzino