The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory in Stroke, Parkinson, and Elderly Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Change of Repeatable Battery for the Assessment of Neuropsychological Status
研究概览
简要总结
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
详细描述
Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ischemic or hemorrhagic cerebrovascular lesion,
- •Parkinson's disease
排除标准
- •With metal implantation
- •Dementia or severe cognitive impairment
研究组 & 干预措施
High frequency rTMS plus fNIRS
rTMS with neuroimage assessment of functional near infrared spectroscopy
干预措施: Functional near infrared spectroscopy (Device)
High frequency rTMS plus fNIRS
rTMS with neuroimage assessment of functional near infrared spectroscopy
干预措施: rTMS (Device)
Sham rTMS
Sham stimulation
干预措施: rTMS (Device)
High frequency rTMS
High frequency rTMS to modulate brain areas
干预措施: rTMS (Device)
结局指标
主要结局
Change of Repeatable Battery for the Assessment of Neuropsychological Status
时间窗: Up to 12 weeks
Test cognition including memory, attention, language...
次要结局
- Change of Montreal Cognitive Assessment(Up to 12 weeks)
- Change of Fugl-Meyer Assessment , Wolf Motor Function Test(Up to 12 weeks)
研究者
vghtpe user
Principal investigator
Taipei Veterans General Hospital, Taiwan