A Phase III Study Evaluating the Efficacy and Safety of CLS2901C in Patients With Osteoarthritis of the Knee
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 96
- 试验地点
- 11
- 主要终点
- KOOS 4 score (The Knee injury and Osteoarthritis Outcome 4 score)
研究概览
简要总结
To evaluate the efficacy and safety of CLS2901C human allogenic chondrocyte sheets used in the osteotomy + RMSC group compared to in the osteotomy alone group of patients with osteoarthritis of the knee (OAK).
详细描述
The investigational human cellular based product is a cell sheet made by culturing and growing chondrocytes taken from cartilage tissue derived from patients with polydactyly. To evaluate the efficacy and safety of CLS2901C human allogenic chondrocyte sheets used in the osteotomy + RMSC group compared to in the osteotomy alone group of patients with osteoarthritis of the knee (OAK). Safety is evaluated by the rate of adverse events and malfunctions. The evaluation period for each group will be approximately 14.5 months, and after the completion of the 52-week evaluation, patients who are available for follow-up will continue to be examined and observed for 5 years after sheets transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female aged 20 to 79 years at informed consent.
- •Diagnosis of OAK classified as Kellgren-Lawrence (K-L) Grade 2 to 4 based on plain lower extremity X-ray.
- •OAK eligible for proximal tibial osteotomy based on the following criteria: Range of motion (ROM): >=120 degree flexion, <=5 degree extension
- •Preoperative cartilage defect of the femoral condyle/trochlear groove or medial tibial condyle with an area of >=4 cm2 per defect site.
- •Total defect area of <=21 cm2 in individuals with multiple cartilage defects.
- •Body mass index (BMI) <
- •No coexisting ligament injury requiring surgery, and no meniscal injury requiring suturing or surgical repair other than partial resection, in the target knee.
- •No history of ligament reconstruction, meniscal suturing, total meniscectomy or bone marrow stimulation, and no history of treatment with regenerative medicine products (including investigational products), cell processing products（including PRP） or gene therapy, in the target knee.
- •No history of treatment with hyaluronic acid products and/or opioid for severe pain in the target knee within 1 month prior to informed consent.
- •No history of treatment with corticosteroid products and/or immunosuppressive drug in the target knee within 3 months prior to informed consent.
- •No history of platelet-rich plasma (PRP) therapy within 6 months prior to informed consent.
- •Non-smoker; provided, however, that smokers will be eligible for study entry if they consent to abstain from smoking from 3 months prior to proximal tibial osteotomy or proximal tibial osteotomy+RMSC until postoperative bone healing.
- •Written informed consent to participate in the study on a voluntary basis.
- •No history of treatment with radiofrequency ablation of peripheral nerves in the knee joint within 1 year prior to informed consent.
- •No history of proximal tibial osteotomy in the non-target knee.
- •No history of treatment using mesenchymal stem cells, mesenchymal stromal cells, or stem cell culture supernatant.
排除标准
- •Requires surgical treatment of the non-target knee during the study period.
- •Any coexisting illness that would interfere with surgery under general anesthesia or that would affect knee surgery.
- •Systemic inflammatory disease such as rheumatoid arthritis.
- •Systemic Active infectious disease such as bacterial, fungal or viral infection.
- •6) Serious disease such as liver disorder, renal disorder, heart disease, lung disease, blood disease or metabolic disease that would make the patient unsuitable for study entry in the opinion of the investigator.
- •7) Diagnosed or suspected malignant tumor or history of malignant tumor within the past 5 years.
- •8) Uncontrolled psychiatric disorder. 9) Poorly-controlled diabetes (HbA1c: >7.0%). 10) septic arthritis of the target knee. 11) Women who are pregnant or breastfeeding, or women of childbearing potential. Women of childbearing potential must agree to use the following contraceptive methods (i.e., contraceptives and medical devices that are approved/certified in Japan) or to abstain completely from sexual intercourse from the time of informed consent and for the study duration (excluding the follow-up period) in order to be eligible for study entry. (a) Primary contraceptive methods: Oral contraceptives, intrauterine devices (IUDs) including progesterone-releasing systems. (b) Adjunctive contraceptive methods: Condoms Use of a primary contraceptive method is mandatory, whereas use of the adjunctive contraceptive method must be in conjunction with a primary contraceptive method. Given that oral contraceptive doses can be missed and that their effects may be diminished when used concomitantly with other medications or dietary health supplements, subjects should consider changing their primary contraceptive method.
- •12) Received treatment as part of another clinical study within the past 6 months, currently participating in another clinical study, or planning to participate in another clinical study while also participating in the present study.
- •13) Known history of hypersensitivity to antibiotics (benzylpenicillin potassium, streptomycin sulfate, amphotericin B).
- •14) Known history of hypersensitivity to bovine-derived materials. 15) Any other reason the investigator deems the subject unsuitable for study entry.
研究组 & 干预措施
the osteotomy + RMSC combination therapy group
the osteotomy + RMSC combination therapy
*RMSC combination therapy R: Resection of unhealthy tissue MS: Marrow arrow Stimulating＝MSCs Recruitment C: Covered by Chondrocyte sheets
干预措施: CLS2901C (human [allogeneic] chondrocyte sheets) (Biological)
结局指标
主要结局
KOOS 4 score (The Knee injury and Osteoarthritis Outcome 4 score)
时间窗: 52 weeks
Absolute change from baseline KOOS4 (Pain, Symptoms, ADL, QOL) score at postoperative Week 52. The four patient-relevant subscales of KOOS are scored separately: KOOS Pain (9items); KOOS Symptoms (7 items); KOOS ADL (17 items); KOOS QOL (4 items). A Likert scale is used and all items have five possible answer options scored from 0 (No Problems) to 4 (Extreme Problems). Scores are transformed to a 0-100 scale, with zero representing extreme knee problems and 100 representing no knee problems as is common in orthopaedic assessment scales and generic measures.
次要结局
未报告次要终点