Conventional Radiography based BT (Controlled Arm) Vs MR-Image Based Brachytherapy (Study Arm) in Locally Advanced Cervical Cancers: A PHASE III Randomized Control Trial

Tata Memorial Centre0 个研究点目标入组 1,050 人开始时间: 待定最近更新: 2021年11月24日

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•Cancer of the uterine cervix considered suitable for curative treatment with definitive radio-(chemo) therapy including MRI guided Brachytherapy.
•Positive biopsy showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.
•Stage IIB/IIIB according to FIGO and TNM guidelines
•Suitable for Brachytherapy boost
•MRI of pelvis at diagnosis is performed
•MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed to rule out para-aortic lymphnode metastasis.
•Patient informed consent

•1.Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin.
•2.Metastatic disease
•3.Previous pelvic or abdominal radiotherapy
•4.Previous total or partial hysterectomy
•5.Combination of preoperative radiotherapy with surgery
•6.Patients receiving BT only
•7.Patients receiving EBRT only
•8.Patients receiving neoadjuvant chemotherapy
•9.Contra indications to MRI
•10.Contra indications to BT
•11.Active infection or severe medical condition endangering treatment delivery.
•12.Pregnant, lactating or childbearing potential without adequate contraception

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