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临床试验/NCT02356887
NCT02356887已完成不适用

Measurement of Flow in Internal Jugular Vein in the Sitting Position: an Ultrasound Study on Healthy Volunteers

Lashmi Venkatraghavan2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2015年2月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
12
试验地点
2
主要终点
Left Internal Jugular Vein Flow

研究概览

简要总结

During neurosurgical procedures, patients need to be placed in sitting position for surgical access especially in surgeries in the vertex or posterior fossa. Due gravitational effect of sitting position the flow in IJV may be reduced. Venous air embolism (VAE) is a common complication of sitting position craniotomy and carries high mortality and morbidity. Venous pressure decreases as the head of the patient is raised above the heart. Hence, negative venous pressure in the cerebral venous system promotes entrapment of air in accidental opening of the sinuses.

Common methods to prevent VAE in sitting position include increasing the venous pressure by either jugular venous compression and/or increasing the venous pressure by adding positive end expiratory pressure (PEEP). Both these methods can decrease venous return and can lead to brain swelling.. In addition, improper neck position can cause the kinking of the IJV which may lead to decreased venous drainage and increased ICP. This has been shown to be the contributing factor for intraoperative brain swelling and postoperative neck and tongue swelling leading to airway obstruction. Optimal brain perfusion is best in the neutral position of the head, but surgery cannot always be performed with this.

详细描述

Currently, there are no studies that looked into the IJV flow in sitting position and effect of venous outflow obstruction on the IJV flow. Valsalva maneuver (forced inspiration with closed glottis) and /or compression of internal jugular veins (IJV) are the two commonly used physiological methods that can cause venous outflow obstruction. A custom made neck collar can be used for compression of internal jugular vein and previous investigations have used a similar device in a rat model to demonstrate the protective effects on slosh-mediated brain injury by increasing intracranial blood volume . While the collars have not yet been studied on people for their effectiveness at preventing concussions, many studies have looked at the effect of neck collars on both jugular compression and ICP..

The purpose of this study is to measure the venous blood flow of healthy volunteers by the use of an ultrasound and Doppler velocimetry in sitting position. the investigators will measure the IJV flow on both sides in sitting position at rest and at two conditions of venous outflow obstruction- 1. Neck compression using a custom made collar and 2. During 30 seconds Valsalva maneuver. This study will provide information on the cerebral venous drainage. This information will be very useful in planning and positioning of patients undergoing neurosurgical procedures and to prevent complications from the improper patient position.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult healthy volunteers who are above the age of 18 ASA 1
  • Body mass index (BMI) less than and equal to 35

排除标准

  • Lack of informed consent
  • Language barrier
  • Medical students and anesthesia residents going through the department as part of their rotation

结局指标

主要结局

Left Internal Jugular Vein Flow

时间窗: 1 day

left internal jugular vein cross-sectional area in the sitting position at rest and with application of the cervical collar.

Right Internal Jugular

时间窗: one day

Comparisons of right internal jugular vein flow in the sitting position at rest and with application of the cervical collar

Internal Jugular Venous Flow

时间窗: 1 day

Right Internal Jugular Vein Flow in the sitting position.

Right Internal Jugular Vein Flow in the Sitting Position

时间窗: one day

Right internal jugular vein peak velocity in the sitting position at rest and with application of the cervical collar

次要结局

  • Left Internal Jugular Vein Flow in the Sitting Position(One day)
  • Left Internal flow in the Sitting Position(One day)

研究者

发起方
Lashmi Venkatraghavan
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Lashmi Venkatraghavan

Assistant Professor, Department of Anesthesia, Toronto Western Hospital, Toronto, Canada

University Health Network, Toronto

研究点 (2)

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