Hantavirus Nephropathy in North-Eastern France : Severity Risk Factors and Prognostic Tools
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Creatinin level
研究概览
简要总结
Hantaviruses are emerging pathogens responsible for hemorrhagic fever with renal syndrome. Severity risks factors aren't consensual in litterature, mostly related to scandinavian cohorts. A prognostic score was created to help patient's orientation in healthcare system but wasn't independantly validated (Hentzien, Emerging infectious diseases 2018).
This retrospective cohort of hantavirus infected hospitalized adults patients in the north-eastern quarter of France between 2013 and 2022 will specify the kidney damage during infection and risk factors for a severe form (defined par acute kidney injury KDIGO 3). The previous prognostic score performance will be evaluated in this cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 125 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hantavirus proven by serology infection
- •age above 18 years
- •Hospitalisation
排除标准
- •age under 18 years
- •fulfill opposition form
结局指标
主要结局
Creatinin level
时间窗: Through study completion, an average of 2 years
Acute Kidney injury KDIGO 3
Hospitalisation in intensive care unit
时间窗: Through study completion, an average of 2 years
Hospitalisation in intensive care unit
Hemorrhagic syndrome
时间窗: Through study completion, an average of 2 years
Major bleeding requiring blood transfusion
Death
时间窗: Through study completion, an average of 2 years
Death
次要结局
- calcium(Through study completion, an average of 2 years)
- Score performance to predict severity(Through study completion, an average of 2 years)
- Proteinuria(Through study completion,an average of 2 years)
- Urinary dipstick(Through study completion, an average of 2 years)
- phosphorus(Through study completion, an average of 2 years)
- sodium(Through study completion, an average of 2 years)
- Heamoglobin(Through study completion, an average of 2 years)
- ALAT, ASAT(Through study completion, an average of 2 years)
- bicarbonate blood level(Through study completion, an average of 2 years)
- potassium(Through study completion, an average of 2 years)
- Urine output(Through study completion, an average of 2 years)
- Hypotension(Through study completion, an average of 2 years)
- platelets level(Through study completion, an average of 2 years)
研究者
CORBEL Alice
Principal investigator
Central Hospital, Nancy, France