Effect of Preoperative Oral Carbohydrates on Postoperative Insulin Resistance in Patients Undergoing OPCAB(Off- Pump Coronary Artery Bypass Surgery)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- postoperative insulin resistance
研究概览
简要总结
Surgical stress creates a state of insulin resistance which has been related to increased postoperative complications. Fasting before surgery induces a catabolic state that contributes to the development of insulin resistance. The aim of this study is to evaluate the effect of preoperative oral carbohydrates on postoperative insulin resistance in patients undergoing OPCAB (off-pump coronary artery bypass surgery). Sixty patients, aged 20 to 79 years, scheduled for OPCAB will be divided into carbohydrate (n=30) and control (n=30) groups. Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before surgery and in the morning of the operation day (3 hours before their scheduled operation). In contrast, patients in the control group consume no food or drink after midnight before their surgery. The primary endpoints are postoperative insulin resistance measured by short insulin tolerance test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who are scheduled to undergo OPCAB
排除标准
- •Subjects are ineligible if they have DM(Diabetes Mellitus),
- •Gastroesophageal reflux disease or gastric emptying disorder,
- •inflammatory bowel disease,
- •previous treatment for intra-abdominal cancer,
- •entered surgery more than 5 hours after ingestion of the morning carbohydrate beverage,
- •cognitive dysfunction,
- •disabling mental change disorder,
- •are unable to communicate or speak Korean
研究组 & 干预措施
carbohydrate group
Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage in the evening before their surgery and in the morning of the operation day (3 hours before their scheduled operation).
干预措施: carbohydrate beverage (Dietary Supplement)
control group
Patients in the control group consume no food or drink after midnight before surgery.
结局指标
主要结局
postoperative insulin resistance
时间窗: within 1 hour after surgery
次要结局
- preoperative discomfort(24 hours)
- perioperative hemodynamic effect(24 hours)
- postoperative complications(24 hours)