NCT05298072Unknown不适用
Identification of Novel Inflammation-related Biomarkers for Early Detection of Anthracycline-induced Cardiotoxicity in Breast Cancer Patients
University Hospital, Essen0 个研究点目标入组 180 人开始时间: 2022年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 180
- 主要终点
- Cardiotoxicity during observational period
研究概览
简要总结
This study aims to identify possible set of inflammatory biomarkers before, during and after anthracycline-based chemotherapy in breast cancer patients to identify (sub)clinical chemotherapy-related cardiac dysfunctionCRCD to identify patients who would benefit from additional cardioprotective therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •initial diagnosis of breast cancer
- •planned Anthracycline-based therapy
- •first-line chemotherapy
- •first visit before initiation of chemotherapy
排除标准
- •previous chemotherapy
- •medical history of cardiac disease
- •inflammation-modulating medication
- •medication with RAS inhibitors
- •pregnancy
- •autoimmune disease
- •drug addictions
- •unwilling or unable to provide informed consent
结局指标
主要结局
Cardiotoxicity during observational period
时间窗: continuous evaluation during observational period of 12 months
Defined according to IC-OS 2021 Consensus Criteria
次要结局
未报告次要终点
研究者
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