Microbial Profiling of Dental Plaque Around Natural Teeth Compared to That of Dental Implants: A Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Microbial profiling of Plaque
研究概览
简要总结
The oral microbiome that colonizes the oral cavity plays a significant role in periodontal health and disease. Periodontitis is a site-specific disease and is initiated by dysbiosis of the subgingival microbiome. Peri-implantitis shares many similarities in pathogenesis with periodontitis. The presence of periodontitis is considered a risk factor for periimplantitis even though the exact mechanism is not clearly understood.
The possibility of microbial transmission for sites with periodontitis to the peri-implant crevice can not be negated. Microbial profiling of early colonizers around implants is poorly understood especially using next-generation sequencing techniques.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Systemically healthy patients with healing abutment of more than 2 weeks duration in at least one implant. Patients belonging to both sexes aged between
- •60 years. At least one periodontal site with pocket depth less than 3mm and no bleeding on probing. At least one periodontal site with pocket depth more than or equal to 4 mm with bleeding on probing.
排除标准
- •Pregnant and lactating females Immunocompromised patients Smokers Use of probiotics, antibiotics, corticosteroids within 3 months before sampling.
结局指标
主要结局
Microbial profiling of Plaque
时间窗: Baseline (0) | 6 months
次要结局
- FMPS(FMBS)
研究者
Irine Paul
PMS College of Dental Science and Research