Cryoablation of the Retrograde Fast Pathway as Treatment for AVNRT
试验速览
- 阶段
- 早期 1 期
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Termination of AVNRT
研究概览
简要总结
In this study a new technique for ablation in atrioventricular nodal reentrant tachycardia using cryo-energy will be studied in cases where the standard approach has higher risk.
详细描述
Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common cause of fast heartbeats in young people. People with AVNRT have two pathways within the heart, the fast pathway (FP) and slow pathway (SP). A treatment for AVNRT is ablation (burning or freezing) of the SP. This can be done with either radiofrequency or cryo-energy. A complication which occurs in 1% of cases is AV block (AVB), meaning the person needs a pacemaker.
Slow pathway ablation is a problem in people when the electrocardiogram (ECG) shows a long PR interval, with greater rates of AVB. This accounts for 5% of AVNRT cases. A possible solution is to treat the FP with cryo-energy and leave the SP intact. This pilot study aims to show this is safe and effective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Documented supraventricular tachycardia (SVT)
- •Planned to undergo electrophysiology (EP) study and ablation
- •PR interval on ECG <220ms (Group 1) or >220ms (Group 2)
排除标准
- •Pregnancy
- •Age <18 years
- •Inability to provide consent
- •High likelihood of tachycardia mechanism other than AVNRT (e.g. Pre-excitation on surface ECG, atrial tachycardia)
结局指标
主要结局
Termination of AVNRT
时间窗: One day
Number of participants where cryotherapy terminates AVNRT
次要结局
- Incidence of AV block(1 year)
- Vascular complications(1 year)
- Cardiac tamponade(1 year)
- Freedom from recurrence(1 year)