Study of the Farnesyl Transferase Inhibitor, R115777, in Combination With Topotecan (NYU 99-32)
试验速览
- 阶段
- 1 期
- 发起方
- 试验地点
- 1
研究概览
简要总结
The purpose of this clinical trial is to establish the safest doses for the combination of a farnesyl transferase inhibitor, R115777 plus topotecan in patients with advanced solid tumors, previously treated or beyond standard therapy of clinical benefit. Maximum tolerated dose, dose limiting toxicity and the activity of this combination will be assessed.
This chemotherapy regimen is a two-pronged attack at the way cancer cells replicate. R115777 is a compound that may inhibit cancer cell growth by interfering with the p21 ras oncogene, while topotecan, a topoisomerase-1 inhibitor, works on cancer cells not subject to control by the ras oncogene. Animal studies suggest that the combination may be synergistic. Another advantage is that R115777 can be taken by mouth.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with advanced solid tumors with previous treatment or beyond standard therapy of significant clinical benefit
- •Therapy with no more than 3 prior chemotherapy regimens
- •Radiotherapy to less than 25% of bone marrow volume (no pelvic radiation)
- •Adequate organ function
- •Recovery from the effects of prior chemotherapy and radiation therapy, with at least a 4 week interval. All prior toxicities should have resolved to baseline prior to entry into the study.
- •Good performance status
- •Anticipate life expectancy of at least 6 months
- •Not pregnant or lactating.
- •Sexually active men and women of childbearing age must use adequate contraception.
- •Be able to give signed, written informed consent.
- •No gastrointestinal condition that could affect the absorption of the drug
- •No active infection requiring systemic medical therapy one week prior to chemotherapy
排除标准
- 未提供