Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D Speckle-tracking Echocardiography
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The changes of echocardiographic and serological indexes were observed by 3D speckled tracking during the 1-year follow-up
研究概览
简要总结
The changes of left ventricular function in patients with sleep apnea were studied by three-dimensional speckle-tracking echocardiography to evaluate the changes of left ventricular function after CPAP treatment
详细描述
Research purposes: (1) Use 3D speckle tracking echocardiography to measure the diastolic and systolic strains of the left atrium and left ventricle of OSAS patients, in order to evaluate the impact and degree of OSA on left ventricular function.
(2) By comparing the changes in the three-dimensional ultrasound strain index of the left ventricle of patients before and after CPAP treatment, and in patients receiving and not receiving CPAP treatment, to evaluate whether CPAP treatment contributes to the improvement of cardiac function in patients with OSAS, and to infer the best suitable intervention population and using time, providing reference basis for clinical treatment.
(3) Discovery of serological indicators that predict the severity of the disease and predict the impairment of heart function Study design: This study is a prospective, observational controlled study. It is planned to include 30 cases of newly diagnosed OSAS patients in the Peking University Third Hospital and a control group selected according to age and gender matching. The three-dimensional strain of the left atrium and left ventricle of the crowd is measured by the 3D speckle tracking technology, and the serological indicators are detected. The OSAS group and the control group were followed up during the course of receiving or not receiving CPAP.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •OSA met the diagnostic criteria of obstructive sleep apnea in the United States Classification of Sleep Diseases in 2014
- •Between the ages of 18 and 80, regardless of gender
- •Sign informed consent
排除标准
- •previously diagnosed patients with heart failure,
- •coronary artery disease,
- •valvular disease,
- •cardiomyopathy,
- •arrhythmia,
- •chronic obstructive/ restrictive pulmonary disease,
- •thyroid dysfunction (including hypothyroidism or hyperthyroidism),
- •already treated with CPAP,
- •poor image quality of echocardiography.
结局指标
主要结局
The changes of echocardiographic and serological indexes were observed by 3D speckled tracking during the 1-year follow-up
时间窗: The follow-up period was 1 year
The changes of echocardiographic indexs such as left ventricular three-dimensional strain and serological indexes including adiponectin.
次要结局
未报告次要终点