The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia

Participants will be invited to participate in a study observing the anesthetic efficacy of the combination of Er,Cr:YSGG laser and surface anesthetic agent on the oral mucosa. This informed consent form provides participants with detailed information to help participants decide whether to participate in this project. Please read it carefully. If participants have any questions, please raise them to the researcher in charge of the study. Investigators will give participants a comprehensive explanation.

Participants' participation in this study is voluntary. This research has been reviewed by the ethics committee of this research institution.

Research purpose: By measuring the anesthetic depth of the combined use of Er,Cr:YSGG water laser and surface anesthetic agent at different time points in the oral vestibule of the mandibular anterior teeth area, to observe the anesthetic efficacy of the combined use of Er,Cr:YSGG water laser and surface anesthetic agent on the oral mucosa.

Research content and process: Before participants are selected for the study, the doctor will ask about participants basic situation, record participants' medical history, and conduct a routine oral examination. The specific requirements are: no allergy to anesthetic drugs, no mucosal lesions, no pregnancy, no systemic diseases, and good health condition.

If participants' above examinations are qualified, participants will follow the following steps for the study: Rest for half an hour to stabilize blood pressure and heart rate. The nurse will put an electrocardiogram monitor on participants to record the changes in blood pressure and heart rate throughout the process. The doctor will select three sites in the vestibule of the mandibular anterior teeth area and irradiate 1 cm away from the site at a 90-degree angle with water laser or ineffective laser for 1 minute, and then randomly apply lidocaine or vaseline to the three sites. The subjects will not rinse their mouths during the experiment. The doctor will insert an aseptic needle into the mucosa at three sites in the mandibular anterior teeth area 10 minutes, 20 minutes, 30 minutes, 40 minutes and 50 minutes after irradiation, and the subjects will raise their hands to indicate "feeling" or "pain" to stop the needle insertion. The doctor will record the depth of needle insertion.