GATA-2 Project: Retrospective and Prospective Exploratory Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 40
- 主要终点
- Time to appearance of spectrum 2, defined as the delay between date of birth and appearance of an event classified as spectrum 2.
研究概览
简要总结
This trial is a translational, open-label, multi-site, retrospective and prospective cohort study of 250 patients aiming to characterize predictive parameters of clonal evolution in a population of subjects carrying the germline GATA2 mutation.
This study will be conducted on a population of subjects either with previous germline GATA2 mutation identified or newly identified for germline GATA2 mutation in the context of routine care.
Prospective cohort:
150 subjects will be included in this interventional prospective cohort study:
- Alive subjects previously identified with a germline GATA2 mutation through the already existing "Neutropenia database";
- Subject identified in the investigating centers in the context of a newly identified germline GATA2 mutation.
For each included patient, biological samples (blood and bone marrow samples) will be collected at baseline visit and then during 5 years, according to the samples taken in the standard practice. No additional sampling will be performed for the study.
Retrospective cohort:
Subjects (100 cases in total) previously identified with germline GATA2 mutation through the already existing "Neutropenia database" and with the following features may enter the retrospective cohort:
- Deceased patients,
- Lost to follow-up patients. Clinical follow-up data will be obtained from this database and/or patient's medical report.
For each retrospective case, archived blood and bone marrow samples (collected in a sanitary setting) will be sent to sponsor's centralized unit for analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All subject, at any age, with a germline GATA2 mutation.
- •Patient followed in the center within a standard of care procedure or clinical trial.
- •Signed written informed consent. For minor patients: patient assent and legal guardian(s) written informed consent obtained before inclusion in the study and prior performance of any study-related procedure.
- •For French patients: patient affiliated to a Social Health Insurance.
排除标准
- •GATA2 somatic mutation.
- •Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure.
- •Person who has forfeited his/her freedom by administrative or legal award or who is under legal protection, with the exception of persons under curatorship who may be included in the study.
结局指标
主要结局
Time to appearance of spectrum 2, defined as the delay between date of birth and appearance of an event classified as spectrum 2.
时间窗: 5 years for each patient
Spectrum 2 corresponds to MDS (Myelodysplastic Syndromes) with excess blasts, AML (Acute myeloid Leukemia) or CMML (Chronic myelomonocytic leukemia).
次要结局
- Time to appearance of spectrum 1, defined as the delay between date of birth and appearance of spectrum 1.(5 years for each patient)
- Time to appearance of first hematological event defined by the delay between date of birth and appearance of first hematological.(5 years for each patient)
- Disease Free Survival (DFS) defined as the time from Leukemia diagnosis until first /relapse or death from any cause.(5 years for each patient)