NCT02910817已完成不适用
Impact of Metformin on In Vitro Fertilization Outcomes in Overweight and Obese Polycystic Ovary Syndrome Women; A Quasi Experimental Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Total number of retrieved oocytes
研究概览
简要总结
RCT to investigate whether metformin co-treatment would improve IVF outcomes in overweight and obese women with PCOS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria restricted the patients to 39 years old with basal FSH < 10 IU/ml and normal TSH and prolacin.
排除标准
- •Exclusion criteria were diabetes mellitus (excluded by GTT), renal or liver disease, associated male factor, documented tubal factor or pelvic adhesions, elevated 17 alfa hydroxyprogesterone level and FSH ≥10 IU/ml. We also excluded the women who started program or medications to reduce their weight and those who their partner has abnormal semen parameters according to the world health organization parameters (WHO, 2010)
研究组 & 干预措施
Metformin-treated group
Experimental
51 overweight and obese women (BMI>24) with PCOS underwent their first fresh autologous IVF-embryo transfer cycle
干预措施: Metformin (Drug)
Placebo
Placebo Comparator
A cohort of fifty-one cross matched PCOS women
干预措施: Placebo (Other)
结局指标
主要结局
Total number of retrieved oocytes
时间窗: Two weeks Metformin treatment
次要结局
- Live birth rate(End of the pregnancy)
研究者
Osama Saber Thabet Abdalmageed
Lecturer of OBGYN in women health hospital
Assiut University
研究点 (1)
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