Monocyte To Large Platelet Ratio As A Diagnostic Marker For Acute Pulmonary Embolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Monocyte-to-Large Platelet Ratio (MLPR)
研究概览
简要总结
A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism
详细描述
The investigators conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE.
- •Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.
排除标准
- •Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation.
- •Patient receiving any anticoagulant drug at a therapeutic dose.
- •Patient with blood transfusion in the last 2 months.
- •Patients with acute coronary syndrome, pulmonary edema.
- •Patient on immunosuppressive drugs , Oral contraceptive pills .
- •Patients with severe renal or hepatic disease.
- •Patients with Stroke.
- •Patients with malignancy.
结局指标
主要结局
Monocyte-to-Large Platelet Ratio (MLPR)
时间窗: At emergency department admission (baseline lab measurement) before any treatment.
A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
次要结局
- Mean platelet volume (MPV)(At emergency department admission (baseline lab measurement) before any treatment.)
- Neutrophil to Lymphocyte Ratio (NLR)(At emergency department admission (baseline lab measurement) before any treatment.)
- D-Dimer Levels(At emergency department admission (baseline lab measurement) before any treatment.)
- Platelet Distribution Width (PDW)(At emergency department admission (baseline lab measurement) before any treatment.)
- Platelet To Lymphocyte Ratio (PLR)(At emergency department admission (baseline lab measurement) before any treatment.)
研究者
Mohamed Kheder Aly Awad
Assistant Lecturer
Ain Shams University