Immune Cells and the Coronavirus for Inflammatory Arthritis
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Prevalence and abundance of CD4+ T lymphocytes
研究概览
简要总结
A team at the University of Manchester are developing a test that tcould be helpful in detecting immunity to the Coronavirus (which causes the COVID-19 disease) in participants with inflammatory arthritis. It is based on a flu assay has already developed; the team will replace the flu antigen with a Coronavirus antigen to see if it is effective.
This project aims to develop a test to see if people who have had the virus have developed immunity to it. This could help to predict who might or might not get the disease a second time, who should stay at home to be protected from potential infection or who will not develop any symptoms, even if exposed to the virus.
When vaccination trials against the Coronavirus will be launched, this test could also help to see if the vaccine is effective.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Has previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study
- •Has agreed to be contacted abut future research projects
- •Has previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study
- •Is willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample
- •Has a good written understanding of English
排除标准
- •Has not previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study
- •Has not agreed to be contacted abut future research projects
- •Has not previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study
- •Is not willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample
- •Has not got a good written understanding of English
结局指标
主要结局
Prevalence and abundance of CD4+ T lymphocytes
时间窗: 2 years
the prevalence and abundance of CD4+ T lymphocytes specifically recognizing SARS-CoV-2 in COVID-19 patients with inflammatory arthritis, in pre- and post-infection samples; in patients without COVID-19 and in healthy volunteers with or without COVID-19. Correlation of these cells with COVID-19 severity.
次要结局
未报告次要终点
研究者
Dr. Sebastien Viatte
Lecturer in Genetics
University of Manchester