L-Citrulline Supplementation to Improve Vascular Function and Responsiveness at Rest and During Exercise in Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Muscle oxygenation during dynamic exercise
研究概览
简要总结
The objective of this project is to provide evidence that L-Citrulline (L-CIT) supplementation can improve vascular function at rest and in response to exercise in postmenopausal women.
详细描述
L-CIT is a non-essential amino acid that is a precursor to L-arginine, the substrate used to produce an important vasodilatory molecule called nitric oxide. The purpose of this study is to identify the effects of 6 grams of L-CIT for 4 weeks on vascular function (endothelial function, blood flow, muscle oxygenation, and blood pressure) at rest and in response to different stressors (cold pressor test, isometric and dynamic exercise).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 79 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal (absence of menstruation > 1 year) between the ages of 50 - 79 years.
- •Sedentary ( < 120 minutes of exercise/week)
- •Resting systolic blood pressure < 150 mmHg and diastolic blood pressure < 90 mmHg
- •Not participating as a subject in another study for at least 2 months prior to the study and for the duration of the study
- •Willingness to abstain from food supplements 1 month prior to the start of the study and throughout the duration of the study
排除标准
- •Body mass index ≥ 40
- •Currently taking more than one vasoactive drug for blood pressure control
- •Cardiometabolic diseases or other chronic diseases
- •Taking hormone replacement therapy 3 months prior to the study
- •Current or prior use of tobacco products
- •More than a moderate intake of alcohol
- •Use of medications and/or supplements that may affect outcome variables
- •Musculoskeletal disorders that will prevent exercise performance
结局指标
主要结局
Muscle oxygenation during dynamic exercise
时间窗: 4 weeks
Muscle oxygenation will be measured using near infrared spectroscopy during dynamic exercises superimposed with the cold pressor test.
Changes in brachial and aortic blood pressure responses via automated sphygmomanometry during metaboreflex activation
时间窗: 4 weeks
Brachial and aortic blood pressures (systolic and diastolic) will be assessed using an arm cuff during isometric handgrip exercise and postexercise muscle ischemia.
Blood flow during dynamic exercise
时间窗: 4 weeks
Blood flow will be measured using ultrasound in the superficial femoral and brachial artery during dynamic exercises superimposed with the cold pressor test.
Microvascular endothelial function
时间窗: 4 weeks
Endothelial function will be assessed via reactive hyperemic index using the EndoPAT device.
Changes in aortic hemodynamics using pulse wave analysis during metaboreflex activation
时间窗: 4 weeks
The speed and reflection pressures, both representing aortic hemodynamic parameters, will be assessed using radial applanation tonometry and a validated transfer function (AtCor Medical) during isometric handgrip exercise and postexercise muscle ischemia.
次要结局
- Changes in brachial and aortic blood pressure responses via automated sphygmomanometry during dynamic plantarflexion exercise and handgrip combined with the cold pressor test(4 weeks)
- Changes in aortic hemodynamics using pulse wave analysis during dynamic plantarflexion exercise and handgrip combined with the cold pressor test(4 weeks)
- Serum nitric oxide levels(4 weeks)
研究者
Arturo Figueroa
Arturo Figueroa, Principal Investigator
Texas Tech University