Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- To validate the CuATSM-PET imaging by correlation to the serum level of osteopontin, a marker of hypoxia
研究概览
简要总结
Hypoxia is a key factor in malignant progression of a neoplasm. It is our aim to explore the basis for quantitative in vivo tumor imaging by Cu-61 diacetyl-bis(N4-methylthiosemicarbazone)PET imaging as a surrogate of tissue hypoxia. We hypothesize that the hypoxia levels are predictive of the tumor response to therapy. Patients will have 2 CU-ATSM PET scans done and the goal is to show spatially stable tracer distributions that correlate with tumor hypoxia. This study will serve as a pilot study for a PO1 submission
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to tolerated a PET/CT scan
- •Age 18 or older
- •Patient being considered for XRT for treatment of their cancer
- •Able to provide written informed consent
排除标准
- •severe claustrophobia or inability to tolerate the PET scan
- •pregnant or breastfeeding women
- •Patients that need supplemental oxygen
- •Patients enrolled in experimental treatments
研究组 & 干预措施
1 CNS
imaging with CuATSM
干预措施: PET-imaging with CuATSM (Procedure)
1 CNS
imaging with CuATSM
干预措施: PET Imaging (Procedure)
2. Head and Neck
Imaging with CuATSM
干预措施: PET CuATSM (Procedure)
3. Lung
imaging with CuATSM
干预措施: PET imaging (Procedure)
4. Prostate
PET imaging with CuATSM
干预措施: PET imaging with CuATSM (Procedure)
5. Esophagus
PET imaging with CuATSM
干预措施: PET imaging with CuATSM (Procedure)
结局指标
主要结局
To validate the CuATSM-PET imaging by correlation to the serum level of osteopontin, a marker of hypoxia
时间窗: end of study
次要结局
- To assess the technical and logistic feasibility of CuATSM-PET scans in a population of cancer patients(end of study)
- To test reliability of the CuATSM uptake by quantifying the reproducibility of the pre-treatment CuATSM_PET scans(end of study)