Effect of Prophylatic Use of Enoxaparin in Women Undergoing in Vitro Fertilization Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Number of participants with detectable fetal heartbeat
研究概览
简要总结
Retrospective study designed to evaluate outcomes in patients undergoing assisted reproduction. Some of them had thrombophilia, and part of them was treated with enoxaparin, started on the day of embryo transfer, and the other part not. Women without thrombophilia formed the control group.
详细描述
A retrospective study was performed to evaluate the results in 104 patients undergoing to assisted reproduction. Women without thrombophilia were included as controls (n=20), while women with thrombophilia were either treated with 40 mg daily of enoxaparin (treated group, n=54), initiated on the day of embryo transfer, and continued to the week 36 of gestation, or did not receive this medication (untreated group, n= 30).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women with female infertility or unexplained infertility
- •Normal sperm analysis
排除标准
- •Women who did not agree with in vitro fertilization techniques
研究组 & 干预措施
Treated Thrombophilia
Women with laboratorial thrombophilia, submitted to in vitro fertilization techniques, and treated with enoxaparin
干预措施: Enoxaparin (Drug)
结局指标
主要结局
Number of participants with detectable fetal heartbeat
时间窗: Day 28
A transvaginal ultrasound was performed for detection of fetal heartbeat
Number of participants with detectable ongoing pregnancy
时间窗: Week 12
Ongoing pregnancy was detected by ultrasound at twelve weeks
Number of participants who delivered a live baby
时间窗: Week 36
Live birth was considered delivery that resulted in at least one live born neonate
次要结局
- Number of participants with biochemical gestation detected(Day 14)
研究者
Luciano de Melo Pompei'
Auxiliary Professor at Gynecology Department
Faculdade de Medicina do ABC