NCT04368143已完成不适用
COVID-19 Immune Repertoire Sequencing
Institute of Tropical Medicine, Belgium1 个研究点 分布在 1 个国家目标入组 84 人开始时间: 2020年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- provide proof-of-concept that (longitudinal) B cell repertoire mining allows identification of emerging virus specific B cell receptor variable regions.
研究概览
简要总结
This concerns a single-center prospective interventional cohort study. Laboratory-confirmed COVID-19 patients will be asked to donate blood at at least two different timepoints. This will allow us to investigate T and B cell evolutions during the course of infection and recovery. The expected duration of the study is four months or the total duration of the SARS-CoV-2 circulation in Belgium (whichever is shortest).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •laboratory confirmed COVID-19 acute infection
- •be older than 18 years of age
- •be hospitalized at the UZA
- •willing and able to provide written informed consent by the participant or its legal representative (for instance in case of medical incapacitation)
排除标准
- •younger than 18 years old
- •Ambulatory patients
结局指标
主要结局
provide proof-of-concept that (longitudinal) B cell repertoire mining allows identification of emerging virus specific B cell receptor variable regions.
时间窗: 4 months
次要结局
- clinical and epidemiological description of UZA hospitalized COVID-19 patients(at hospitalization)
- study evolutions in B and T cell repertoires to understand COVID-19 specific immune responses fundamentally.(every 7 days during hospitalization a bloodsample is taken)
研究者
研究点 (1)
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