A Prospective Clinical Study of Long-term Effects of SCL-wearing on Corneal Neuromediators and Postoperative Rehabilitation After SMILE

Quality of Vision (QOV) scores

时间窗: baseline, 1 month, 3months, 6months

It consists of 10 items related to visual symptoms, including glare, halo, radiating light, foggy vision, blurred vision, visual distortion, diplopia, visual fluctuation, difficulty in focusing and difficulty in depth perception. Each item consists of three dimensions: frequency, severity and degree of distress. Therefore, this questionnaire contains a total of 30 questions. The answers to the above three dimensions respectively include four options, namely frequency: never, occasionally, often, and frequently; Severity: None, mild, moderate, severe; Degree of distress: None, a little, some, very much. The corresponding scores for the four options are 0, 1, 2, and 3 respectively. The higher the score, the worse the visual quality

contrast sensitivity function

时间窗: baseline, 1moth, 3 moths, 6 months

Under sufficient correction conditions, dark adaptation lasted for 10 minutes. Using the CSV-1000 contrast sensitivity tester at a distance of 3 meters, under the conditions of bright vision (85 cd/m ²), bright glare (135 lx), dark vision (3 cd/m ²), and dark glare (28 lx) respectively, Test the highest CS level that can be distinguished at 3, 6, 12 and 18 c/d spatial frequencies one by one. At each spatial frequency, the examinee needs to point out the bar grid sight in the upper and lower two circular sight targets and report the direction of the bar grid. After the result is correct, gradually reduce the bar grid contrast until the examinee can no longer recognize it. The inverse of the lowest recognizable contrast at this time is the contrast sensitivity. Record in logarithmic units according to the grade value conversion table.

Corneal subepithelial nerve fibers

时间窗: baseline, 1moth, 3 moths, 6 months

In this study, the ACCMetrics V.2 software developed by the University of Manchester in the UK for the HRT confocal microscope of Heidelberg Company was used to conduct automatic quantitative analysis and data recording on three nerve fiber images at different positions selected in a single shoot. The parameters analyzed include corneal nerve fiber density (CNFD sterand/mm 2) and corneal nerve fiber length( CNFL, mm/mm 2), corneal nerve fiber area (CNFA mm2/mm 2), corneal nerve fiber width (CNFW mm ), etc. Each inspection is carried out by the same inspector to reduce subjective errors.

Corneal stromal lenticule Neuromediators

时间窗: baseline

Corneal neuromediators, including NGF(pg/mL), CGRP(pg/mL), SP(pg/mL), IGFBP-1(ng/mL), and MANF(pg/mL), which play pivotal roles in maintaining normal physiological functions of the cornea.

OSDI Questionnaire

时间窗: baseline, 1moth, 3 moths, 6 months

The impact of dry eye on the subjective symptoms of patients was evaluated from three dimensions: ocular symptoms, visual function, and environmental stimuli. There were a total of 12 items. Each symptom was divided into 5 levels according to the degree and occurrence frequency: 0 was considered as none. 1 point occurs sometimes; 2 minutes occurs approximately half of the time; 3 points occur frequently; 4 points occur continuously. The final OSDI score = the total of all scores ×100/ (the total number of assessment questions ×4), with a total score ranging from 0 to 100.