Effect of Pulsatile Pressure and Long Sleep Duration on Cerebral Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed
研究概览
简要总结
Sleep duration has received much attention in recent years due to strong evidence that not enough sleep can increase risk for a number of diseases and disorders. Research is emerging that too much sleep also has a negative impact on health, particularly higher risk for myocardial infarction and stroke. The investigators hypothesize that long duration sleep has the ability to impair peripheral and cerebral vascular function in middle-aged to older adults.
详细描述
The aim of this study is to compare the effect of long duration sleep (>9 hours) to recommended levels of sleep (7-8 hours) in a crossover designed study requiring adults to maintain each prescribed sleep duration for one week. Ambulatory brachial and central aortic blood pressure will be measured during sleep, while cerebrovascular reactivity, carotid artery hemodynamics (e.g., flow pulsatility), aortic pulse wave reflections, cognitive function, and peripheral vasodilatory function will be measured before and after each sleep protocol. A secondary objective of this study is to understand whether aerobic exercise can improve vascular function under conditions of different sleep durations. This information will shed light upon the impact of sleep parameters on exercise-induced improvements in vascular function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •recreationally active
- •reporting no recent history of sleep problems
- •not taking sleep-inducing medication
- •not diabetic (fasting blood glucose <126 mg/dL)
排除标准
- •show symptoms of insomnia
- •have a personal history of stroke or diabetes
- •take birth control pills
研究组 & 干预措施
8 hours time in bed
Participants will be asked to spend 8 hours time in bed with the aim of achieving one week of normal sleep duration (7 to 8 hours).
干预措施: Sleep duration (Behavioral)
11 hours time in bed
Participants will be asked to spend 11 hours time in bed with the aim of achieving one week of long duration sleep as defined as 9+ hours of sleep.
干预措施: Sleep duration (Behavioral)
结局指标
主要结局
Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed
时间窗: One night during each time in bed condition
Central aortic pulse pressure was measured one night during the week of 8 hours in bed, then again one night during the week of 11 hours in bed. Blood pressure was measured using an Oscar2 ambulatory blood pressure device. The device started recordings one hour prior to sleep and was programmed to take measurements once every 30 minutes during sleep until 10:00pm then every 45 minutes after 10:00pm until participants arose from bed. The change in central aortic pulse pressure from being awake to being asleep was compared between 8 and 11 hours in bed conditions.
Change in Cerebral Vascular Reactivity After 11 Hours in Bed
时间窗: Morning after one week of 8 and 11 hours in bed
Blood flow measured in the middle cerebral artery during hypercapnia was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Cerebral blood flow was measured using transcranial Doppler during 3 minutes of transient hypercapnia induced by rebreathing. Cerebral vascular reactivity was considered as the percent increase in cerebral blood flow at the end of 3 minutes of rebreathing relative to the Torr change in end-tidal carbon dioxide (percent change/Torr).
Change in Arterial Stiffness After 11 Hours in Bed
时间窗: Morning after one week of 8 and 11 hours in bed
Arterial stiffness was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Carotid-femoral pulse wave velocity was used as the measure of arterial stiffness. Radial arterial tonometry was used to derive a central aortic blood pressure wave. Wave separation analysis of the aortic pressure wave was then used to calculate pulse wave velocity from transit time and carotid-femoral path length.
Change in Peak Reactive Hyperemia After 11 Hours in Bed
时间窗: Morning after one week of 8 and 11 hours in bed
Peak forearm blood flow was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Peak reactive hyperemia in the forearm (ml/100ml/min) was measured using venous occlusion plethysmography after 10 minutes of forearm ischemia resulting from blood pressure cuff inflation at the upper-arm. Peak blood flow was considered the highest blood flow measurement after the blood pressure cuff was deflated.
次要结局
- Change in Spatial Orientation After Aerobic Exercise(Baseline and after exercise)
- Change in Mental Flexibility After Aerobic Exercise(Baseline and after exercise)
- Change in Executive Function After Aerobic Exercise(Baseline and after exercise)
研究者
Joaquin U Gonzales, PhD
Associate Professor
Texas Tech University