2024-513799-16-00招募中4 期
Acetazolamide in combination with SGLT2i in patients with volume overload and acute heart failure
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 24-hour sodium excretion
研究概览
简要总结
Improvement in natriuresis
入排标准
- 年龄范围
- 18 years 至 65+ years（65+ Years, 18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •Heart Failure
- •Maintenance therapy with loop diuretics of at least 40mg of furosemide or equivalents
- •Deemed volume overloaded by treating cardiologist warranting the addition of SGLT2i and IV loop diuretic therapy
排除标准
- •Kidney function impairment with an eGFR <20ml/min/1.73m² (result within last 6 months)
- •Inability to collect 24h urine collections
- •Systolic blood pressure below 90mmHg
结局指标
主要结局
24-hour sodium excretion
24-hour sodium excretion
次要结局
- 24-hour volume output
- Weight change
- Congestion assessment according to the ADVOR protocol
- Plasma volume changes
- Changes in neurohormonal stimulation (renin, aldosterone)
- Changes in POCUS (Heart, IVC, lung, abdomen, JVP)
研究者
Clinical Trial Unit
Scientific
Ziekenhuis Oost Limburg
研究点 (1)
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