Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training
研究概览
简要总结
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties.
The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Coronary artery disease
- •Normal HDL-cholesterol levels in blood:
- •> 40 mg/dl (1.03 mmol/L) in males
- •> 50 mg/dl (1.29 mmol/L) in females
排除标准
- •Type 1 or 2 diabetes mellitus
- •Acute coronary syndrome
- •Unstable angina pectoris
- •Myocardial infarction during the last 8 weeks
- •Therapy with niacin
- •Active infections
- •Ventricular arrhythmias
- •Systolic blood pressure > 160 mmHg or diastolic blood pressure > 95 mmHg
- •Pregnant or lactating
- •Alcoholism
结局指标
主要结局
vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training
次要结局
- flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound